ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2013
Early fish introduction and neonatal antibiotics affect the risk of asthma into school age.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Effects of Early Diet on the Prevalence of Allergic Disease in Children: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review.BMC pediatrics · 2020Pooled it
- [Association between use of antibacterial agents in the first year of life and childhood asthma: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Pooled it
- Neonatal and early infancy antibiotic exposure is associated with childhood atopic dermatitis, wheeze and asthma.European journal of pediatrics · 2024Article
- Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study.Frontiers in allergy · 2024Article
- The Effects of a Healthy Diet on Asthma and Wheezing in Children and Adolescents: A Systematic Review and Meta-Analysis.Journal of asthma and allergy · 2023Review
- Maternal prenatal psychological distress associates with offspring early-life wheezing - FinnBrain Birth Cohort.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
- S3 guideline Allergy Prevention.Allergologie select · 2022Article
- Clinical outcomes following pre-, pro- and synbiotic supplementation after caesarean birth or antibiotic exposure in the first week of life in term born infants: A systematic review of the literature.Frontiers in pediatrics · 2022Review
- Association of infant antibiotic exposure and risk of childhood asthma: A meta-analysis.The World Allergy Organization journal · 2021Article
- Parental questionnaires provided reliable data on childhood asthma compared with national registers.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Article
- Review
- Preventing Atopic Diseases During Childhood - Early Exposure Matters.Frontiers in immunology · 2021Review
- Dietary Interventions and Nutritional Factors in the Prevention of Pediatric Asthma.Frontiers in pediatrics · 2020Review
- Fish, Shellfish, and Children's Health: An Assessment of Benefits, Risks, and Sustainability.Pediatrics · 2019Article
- Higher parental education was associated with better asthma control.Acta paediatrica (Oslo, Norway : 1992) · 2019Article
- Introduction of fish and other foods during infancy and risk of asthma in the All Babies In Southeast Sweden cohort study.European journal of pediatrics · 2019Article
- Are There Potential Applications of Fecal Microbiota Transplantation beyond Intestinal Disorders?BioMed research international · 2019Review
- Antibiotics in the first week of life were associated with atopic asthma at 12 years of age.Acta paediatrica (Oslo, Norway : 1992) · 2018Article
- Perinatal antibiotic exposure alters composition of murine gut microbiota and may influence later responses to peanut antigen.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe early introduction of fish has been reported to reduce the risk of wheezing disorder in early childhood, while broad-spectrum antibiotics in the first week have been associated with an increased risk. However, it is uncertain whether the effects remain into school age. The aim was to explore these risk factors for doctor-diagnosed asthma at 8 years.
methodsData were obtained from a prospective, longitudinal study of a cohort of children born in western Sweden. The parents answered questionnaires at 6 months and 1, 4.5 and 8 years of age. The response rate at 8 years was 80% of the questionnaires distributed (4051/5044), that is, 71% of the families entering the study (4051/5654).
resultsAt 8 years, 5.7% reported current doctor-diagnosed asthma. Of these, 65% had atopic asthma and 35% non-atopic asthma. In the multivariate analysis, atopic heredity, male gender and own allergic disease during infancy were risk factors for doctor-diagnosed asthma at 8 years. In addition, the introduction of fish before the age of 9 months independently reduced the risk (adjusted OR 0.6; 95% CI 0.4-0.96), while broad-spectrum antibiotics in the first week independently increased the risk of current asthma at school age (aOR 2.3; 1.2-4.2). Regarding types of asthma, the effects were significant in atopic asthma but not in non-atopic asthma.
conclusionThe early introduction of fish and neonatal antibiotic treatment influence the risk of asthma into school age. The significant effect on atopic asthma is of particular importance, as this phenotype is of major clinical significance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.