ArticleBMC biology2013
Biological functions of natural antisense transcripts.
Article in BMC biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- The Roles of Antisense Long Noncoding RNAs in Tumorigenesis and Development through Cis-Regulation of Neighbouring Genes.Biomolecules · 2023Review
- Recent insights into the functions and mechanisms of antisense RNA: emerging applications in cancer therapy and precision medicine.Frontiers in chemistry · 2023Review
- Sense and antisense RNA products of theFrontiers in molecular biosciences · 2023Article
- Navigating the Multiverse of Antisense RNAs: The Transcription- and RNA-Dependent Dimension.Non-coding RNA · 2022Review
- Antisense lncRNA NNT-AS1 promoted esophageal squamous cell carcinoma progression by regulating its sense gene NNT expression.Cell death discovery · 2022Article
- Long Non-coding RNA ZFPM2-AS1: A Novel Biomarker in the Pathogenesis of Human Cancers.Molecular biotechnology · 2022Review
- Overlapping genes in natural and engineered genomes.Nature reviews. Genetics · 2022Review
- Review
- Small Activating RNAs: Towards the Development of New Therapeutic Agents and Clinical Treatments.Cells · 2021Review
- Characterization of basal and estrogen-regulated antisense transcription in breast cancer cells: Role in regulating sense transcription.Molecular and cellular endocrinology · 2020Article
- Long non coding RNAs and ALS: Still much to do.Non-coding RNA research · 2018Review
- ZFPM2-AS1, a novel lncRNA, attenuates the p53 pathway and promotes gastric carcinogenesis by stabilizing MIF.Oncogene · 2018Article
- A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability.PLoS genetics · 2018Article
- Transcriptomic analyses of rice (Oryza sativa) genes and non-coding RNAs under nitrogen starvation using multiple omics technologies.BMC genomics · 2018Article
- Modeling the interactions of sense and antisense Period transcripts in the mammalian circadian clock network.PLoS computational biology · 2018Article
- linc00673 (ERRLR01) is a prognostic indicator of overall survival in breast cancer.Transcription · 2018Article
- Silencing of endogenous retroviruses by heterochromatin.Cellular and molecular life sciences : CMLS · 2017Review
- Natural antisense transcripts are significantly involved in regulation of drought stress in maize.Nucleic acids research · 2017Article
- High-throughput sequencing of human plasma RNA by using thermostable group II intron reverse transcriptases.RNA (New York, N.Y.) · 2016Article
- RNA sequencing provides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
In theory, the human genome is large enough to keep its roughly 20,000 genes well separated. In practice, genes are clustered; even more puzzling, in many cases both DNA strands of a protein coding gene are transcribed. The resulting natural antisense transcripts can be a blessing and curse, as many appreciate, or simply transcriptional trash, as others believe. Widespread evolutionary conservation, as recently demonstrated, is a good indicator for potential biological functions of natural antisense transcripts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.