Trial reportNeural plasticity2013
Different current intensities of anodal transcranial direct current stimulation do not differentially modulate motor cortex plasticity.
Trial report in Neural plasticity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson's disease: a systematic review.Journal of neuroengineering and rehabilitation · 2020Pooled it
- The effect of high-definition transcranial direct current stimulation intensity on motor performance in healthy adults: a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2021Trial
- Increased leg muscle fatigability during 2 mA and 4 mA transcranial direct current stimulation over the left motor cortex.Experimental brain research · 2020Trial
- Expanding the parameter space of anodal transcranial direct current stimulation of the primary motor cortex.Scientific reports · 2019Trial
- Transcranial direct current stimulation over the sensory-motor regions inhibits gamma synchrony.Human brain mapping · 2019Trial
- Can electric fields explain inter-individual variability in transcranial direct current stimulation of the motor cortex?Scientific reports · 2019Trial
- The ipsilateral corticospinal responses to cross-education are dependent upon the motor-training intervention.Experimental brain research · 2018Trial
- M1 a-tDCS does not acutely enhance motor skill acquisition of a dexterous, timing-based videogame task in adults.Physiological reports · 2026Article
- Transcranial focused ultrasound induces source localizable cortical activation in resting state humans when applied concurrently with transcranial electric stimulation.Nature communications · 2026Article
- What are the optimal transcranial direct current stimulation parameters and design elements to modulate corticospinal excitability? A systematic review and longitudinal meta-analysis.Neurological research and practice · 2025Review
- Dose-response of tDCS effects on motor learning and cortical excitability: A preregistered study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Optimising transcranial direct current stimulation application for the enhancement of exercise performance: a review.Frontiers in physiology · 2025Review
- A Literature Review on Optimal Stimulation Parameters of Transcranial Direct Current Stimulation for Motor Recovery After Stroke.Brain & NeuroRehabilitation · 2024Review
- Metaplastic neuromodulation via transcranial direct current stimulation has no effect on corticospinal excitability and neuromuscular fatigue.Experimental brain research · 2024Article
- Small effects of electric field on motor cortical excitability following anodal tDCS.iScience · 2024Article
- Neurobiological regulation of eating behavior: Evidence based on non-invasive brain stimulation.Reviews in endocrine & metabolic disorders · 2022Review
- Auditory driven gamma synchrony is associated with cortical thickness in widespread cortical areas.NeuroImage · 2022Article
- Short periods of bipolar anodal TDCS induce no instantaneous dose-dependent increase in cerebral blood flow in the targeted human motor cortex.Scientific reports · 2022Article
- Inter-Individual Variability in tDCS Effects: A Narrative Review on the Contribution of Stable, Variable, and Contextual Factors.Brain sciences · 2022Review
- Effects of Transcranial Direct Current Stimulation on Brain Electrical Activity, Heart Rate Variability, and Dual-Task Performance in Healthy and Fibromyalgia Women: A Study Protocol.Behavioral sciences (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial direct current stimulation (tDCS) is a noninvasive technique that modulates the excitability of neurons within the motor cortex (M1). Although the aftereffects of anodal tDCS on modulating cortical excitability have been described, there is limited data describing the outcomes of different tDCS intensities on intracortical circuits. To further elucidate the mechanisms underlying the aftereffects of M1 excitability following anodal tDCS, we used transcranial magnetic stimulation (TMS) to examine the effect of different intensities on cortical excitability and short-interval intracortical inhibition (SICI). Using a randomized, counterbalanced, crossover design, with a one-week wash-out period, 14 participants (6 females and 8 males, 22-45 years) were exposed to 10 minutes of anodal tDCS at 0.8, 1.0, and 1.2 mA. TMS was used to measure M1 excitability and SICI of the contralateral wrist extensor muscle at baseline, immediately after and 15 and 30 minutes following cessation of anodal tDCS. Cortical excitability increased, whilst SICI was reduced at all time points following anodal tDCS. Interestingly, there were no differences between the three intensities of anodal tDCS on modulating cortical excitability or SICI. These results suggest that the aftereffect of anodal tDCS on facilitating cortical excitability is due to the modulation of synaptic mechanisms associated with long-term potentiation and is not influenced by different tDCS intensities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.