ArticleISRN hematology2013
Hemoglobin A2 Lowered by Iron Deficiency and α -Thalassemia: Should Screening Recommendation for β -Thalassemia Change?
Article in ISRN hematology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Assessment of diagnostic accuracy of Gazelle: A point-of-care testing device for screening β-thalassemia trait.The Indian journal of medical research · 2024Review
- Unresolved laboratory issues of the heterozygous state of β-thalassemia: a literature review.Haematologica · 2024Review
- Significance of borderline HbAScientific reports · 2022Article
- Thalassemia and erythroid transcription factorArchives of medical science : AMS · 2022Article
- Nationwide carrier detection and molecular characterization of β-thalassemia and hemoglobin E variants in Bangladeshi population.Orphanet journal of rare diseases · 2020Article
- Consensus Statement by an Expert Panel on the Diagnosis and Management of Iron Deficiency Anemia in the Gulf Cooperation Council Countries.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020Article
- Optimization and application of a dried blood spot-based genetic screening method for thalassemia in Shenzhen newborns.World journal of pediatrics : WJP · 2019Article
- Higher minor hemoglobin A2 levels in multiple sclerosis patients correlate with lesser disease severity.Neuropsychiatric disease and treatment · 2016Article
- A Large Cohort Study of Genotype and Phenotype Correlations of Beta- Thalassemia in Iranian Population.International journal of hematology-oncology and stem cell research · 2015Article
- Haemoglobinopathies in eastern Indian states: a demographic evaluation.Journal of community genetics · 2015Article
- Detection of Abnormal Hemoglobin Variants by HPLC Method: Common Problems with Suggested Solutions.International scholarly research notices · 2014Article
- Spectrum of hemoglobinopathies with hematological and biochemical profile: A five year experience from a tertiary care hospital.Pakistan journal of medical sciencesArticle
- Challenges Associated with the Identification of Abnormal Hemoglobin Variants Utilizing the High-performance Liquid Chromatograph Technique: A Prospective Study in a Hospital Setting in Gujarat.International journal of applied & basic medical researchArticle
- The importance of hemoglobin A2 determination.Revista brasileira de hematologia e hemoterapiaArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Screening for β -thalassemia trait (BTT) relies on measuring hemoglobin (Hb) A2. Since multiple factors can affect HbA2 levels, the screening can become unreliable. In 1356 healthy Arabs enrolled into a federally funded premarital BTT screening program, the effects of iron deficiency (ID), α (+)-thalassemia trait, gender, smoking, and tribalism on HbA2 were studied. The complete blood count and hemoglobin fractions were determined on the entire cohort; serum ferritin (<15 μ g/L) in 391 subjects was used to determine ID. BTT was present in 29 (2.1%) subjects (HbA2 > 3.5%). Among 77(20.3%) subjects with ID, the mean HbA2 (2.30 ± 0.23%) was 0.2% lower than in subjects without iron deficiency (2.50 ± 0.24%, P < 0.0001). In 65 (38%)/172 subjects with phenotypic α (+)-thalassemia trait, the mean HbA2 (2.43 ± 0.24%) was 0.13% lower than in subjects without α (+)-thalassemia trait, P < 0.0001. The mean HbA2 did not differ between males and females, smokers and nonsmokers, and between the tribes. Thus, 35 (2.6%) subjects with HbA2 between 3.2 and 3.5% were at a risk of false negative diagnosis of BTT. Since iron deficiency and α (+)-thalassemia are both common and both lower HbA2, modifications in screening recommendations for BTT are proposed.
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Registered trials
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