Evidence map›Paper›PMID 23577239›Full record

ReviewJournal of obesity2013

Genetics of obesity and type 2 diabetes in African Americans.

Shana McCormack, Struan F A Grant

Abstract readReview
In one paragraph

Review in Journal of obesity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Examining Community Engagement Research Strategies Used in Flint, Michigan: The Church Challenge.Progress in community health partnerships : research, education, and action · 2023
    Article
  5. Article
  6. Functional genomic characterization of thePhysiological genomics · 2019
    Article
  7. Article
  8. Article
  9. Article
  10. Genomics of Colorectal Cancer in African Americans.Next generation, sequencing & applications · 2016
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shana McCormackDivision of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Struan F A Grant

Funding

Genome Wide Association Study for Childhood ObesityR01HD056465 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A · 2008 to 2024
$9.5M
Career Development Program in Pediatric Diabetes Research (K12) at CHOPK12DK094723 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI WILLI, STEVEN M · 2011 to 2020
$3.6M
NICHD NIH HHS R01 HD056465NIDDK NIH HHS K12 DK094723
6 · The paper itself

Abstract

Obesity and type 2 diabetes are highly prevalent and lead to significant morbidity and mortality. In the United States, the impact of these conditions may be worse on historically underserved minorities, particularly African Americans. Genetic ancestry and differences in physiology are unlikely to be the sole or primary determinants of these disparities. In addition, research in this area has the ethically problematic possibility of conflating race with biology. Despite these important considerations and the challenges of conducting this work, population-based approaches for investigating the etiology of obesity and T2D may yield useful information about the pathophysiology of disease, and have implications that extend to all affected individuals. The purpose of this paper is to describe what is understood about the genetic variation that underlies obesity and T2D in African Americans and other individuals of more recent African descent and to highlight several examples that illustrate how ensuring adequate minority representation in genetic research improves its quality. For a variety of reasons a number of unique insights have been possible as a result of these efforts.

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOBlack or African AmericanBody Mass IndexDiabetes Mellitus, Type 2Genome-Wide Association StudyHumansObesityPolymorphism, Single NucleotideProteinsReceptor, Melanocortin, Type 4Transcription Factor 7-Like 2 ProteinUnited StatesAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanProteinsReceptor, Melanocortin, Type 4TCF7L2 protein, humanTranscription Factor 7-Like 2 Protein

Identifiers

PMID23577239
PMCPMC3614120

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.