ArticleeLife2013
Improved use of a public good selects for the evolution of undifferentiated multicellularity.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
83 citing papers in PubMed, 148 citations in OpenAlex.
- Review
- Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype.eLife · 2026Article
- Genetic and environmental determinants of multicellular-like phenotypes in fission yeast.Genetics · 2026Article
- The Evolutionary and Ecological Consequences of Cooperation.The American naturalist · 2026Review
- Article
- Combinatorial engineering approaches for improved lipid production in Saccharomyces cerevisiae.FEMS yeast research · 2026Article
- Behavioural ecology in the twenty-first century.Nature ecology & evolution · 2025Review
- Compensatory evolution to DNA replication stress is robust to nutrient availability.Molecular systems biology · 2025Article
- The B-type cyclin Clb4 prevents meiosis I sister centromere separation in budding yeast.G3 (Bethesda, Md.) · 2025Article
- Co-regulation of cooperative and private traits by PsdR inEvolution letters · 2025Article
- An anticipatory mechanism enhances the cooperative behaviors of quorum sensing mutants in Pseudomonas aeruginosa.PLoS pathogens · 2025Article
- Experimental evolution of yeast shows that public-goods upregulation can evolve despite challenges from exploitative non-producers.Nature communications · 2024Article
- A dynamic network model predicts the phenotypes of multicellular clusters from cellular properties.Current biology : CB · 2024Article
- Increased privatization of a public resource leads to spread of cooperation in a microbial population.Microbiology spectrum · 2024Article
- Optogenetic spatial patterning of cooperation in yeast populations.Nature communications · 2024Article
- Multicellular growth as a dynamic network of cells.bioRxiv : the preprint server for biology · 2023Article
- Multispecies interactions shape the transition to multicellularity.Proceedings. Biological sciences · 2023Article
- A Zpr1 co-chaperone mediates folding of eukaryotic translation elongation factor 1A via a GTPase cycle.Molecular cell · 2023Article
- Single-cell adaptations shape evolutionary transitions to multicellularity in green algae.Nature ecology & evolution · 2023Article
- Alternating selection for dispersal and multicellularity favors regulated life cycles.Current biology : CB · 2023Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
We do not know how or why multicellularity evolved. We used the budding yeast, Saccharomyces cerevisiae, to ask whether nutrients that must be digested extracellularly select for the evolution of undifferentiated multicellularity. Because yeast use invertase to hydrolyze sucrose extracellularly and import the resulting monosaccharides, single cells cannot grow at low cell and sucrose concentrations. Three engineered strategies overcame this problem: forming multicellular clumps, importing sucrose before hydrolysis, and increasing invertase expression. We evolved populations in low sucrose to ask which strategy they would adopt. Of 12 successful clones, 11 formed multicellular clumps through incomplete cell separation, 10 increased invertase expression, none imported sucrose, and 11 increased hexose transporter expression, a strategy we had not engineered. Identifying causal mutations revealed genes and pathways, which frequently contributed to the evolved phenotype. Our study shows that combining rational design with experimental evolution can help evaluate hypotheses about evolutionary strategies. DOI:http://dx.doi.org/10.7554/eLife.00367.001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.