ArticleFrontiers in genetics2013
Epigenetics in radiation biology: a new research frontier.
Article in Frontiers in genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 91 citations in OpenAlex.
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- Ionising radiation exposure-induced regulation of selected biomarkers and their impact in cancer and treatment.Frontiers in nuclear medicine · 2024Review
- Dose rate dependent reduction in chromatin accessibility at transcriptional start sites long time after exposure to gamma radiation.Epigenetics · 2023Article
- Stress Management in Plants: Examining Provisional and Unique Dose-Dependent Responses.International journal of molecular sciences · 2023Review
- Transcriptomes of Wet Skin Biopsies Predict Outcomes after Ionizing Radiation Exposure with Potential Dosimetric Applications in a Mouse Model.Current issues in molecular biology · 2022Article
- Differential molecular response in mice and human thymocytes exposed to a combined-dose radiation regime.Scientific reports · 2022Article
- Radiomic and radiogenomic modeling for radiotherapy: strategies, pitfalls, and challenges.Journal of medical imaging (Bellingham, Wash.) · 2021Review
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- Epigenetic Regulation of the Hippocampus, with Special Reference to Radiation Exposure.International journal of molecular sciences · 2020Review
- Ionizing Radiation-Induced Epigenetic Modifications and Their Relevance to Radiation Protection.International journal of molecular sciences · 2020Review
- Cancer Radiotherapy: Understanding the Price of Tumor Eradication.Frontiers in cell and developmental biology · 2020Article
- Nitric Oxide Is Involved in Heavy Ion-Induced Non-Targeted Effects in Human Fibroblasts.International journal of molecular sciences · 2019Article
- Gamma radiation induces locus specific changes to histone modification enrichment in zebrafish and Atlantic salmon.PloS one · 2019Article
- Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish.Scientific reports · 2018Article
- Adverse effects of paternal chemotherapy exposure on the progeny brain: intergenerational chemobrain.Oncotarget · 2018Article
- Understanding low radiation background biology through controlled evolution experiments.Evolutionary applications · 2017Article
- Low dose radiation effects on the brain - from mechanisms and behavioral outcomes to mitigation strategies.Cell cycle (Georgetown, Tex.) · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of people that receive exposure to ionizing radiation (IR) via occupational, diagnostic, or treatment-related modalities is progressively rising. It is now accepted that the negative consequences of radiation exposure are not isolated to exposed cells or individuals. Exposure to IR can induce genome instability in the germline, and is further associated with transgenerational genomic instability in the offspring of exposed males. The exact molecular mechanisms of transgenerational genome instability have yet to be elucidated, although there is support for it being an epigenetically induced phenomenon. This review is centered on the long-term biological effects associated with IR exposure, mainly focusing on the epigenetic mechanisms (DNA methylation and small RNAs) involved in the molecular etiology of IR-induced genome instability, bystander and transgenerational effects. Here, we present evidence that IR-mediated effects are maintained by epigenetic mechanisms, and demonstrate how a novel, male germline-specific, small RNA pathway is posited to play a major role in the epigenetic inheritance of genome instability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.