ArticleFrontiers in computational neuroscience2013
Reduction in LFP cross-frequency coupling between theta and gamma rhythms associated with impaired STP and LTP in a rat model of brain ischemia.
Article in Frontiers in computational neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 58 citations in OpenAlex.
- Cross-frequency coupling between low frequency and gamma oscillations altered in cognitive biotype of depression.Frontiers in psychiatry · 2025Article
- Unleashing the potential: 40 Hz multisensory stimulation therapy for cognitive impairment.Journal of central nervous system disease · 2025Review
- Mystery of gamma wave stimulation in brain disorders.Molecular neurodegeneration · 2024Review
- Long-range and cross-frequency neural modulation of gamma flicker on vigilance decrement.Cognitive neurodynamics · 2024Article
- Pro-myelinating clemastine administration improves recording performance of chronically implanted microelectrodes and nearby neuronal health.Biomaterials · 2023Article
- Non-Stationary Dynamic Mode Decomposition.bioRxiv : the preprint server for biology · 2023Article
- Non-Stationary Dynamic Mode Decomposition.IEEE access : practical innovations, open solutions · 2023Article
- VEGF Modulates the Neural Dynamics of Hippocampal Subregions in Chronic Global Cerebral Ischemia Rats.Neuromolecular medicine · 2021Article
- Estimating Phase Amplitude Coupling between Neural Oscillations Based on Permutation and Entropy.Entropy (Basel, Switzerland) · 2021Article
- What Can Local Transfer Entropy Tell Us about Phase-Amplitude Coupling in Electrophysiological Signals?Entropy (Basel, Switzerland) · 2020Article
- Enriched Environment and Social Isolation Affect Cognition Ability via Altering Excitatory and Inhibitory Synaptic Density in Mice Hippocampus.Neurochemical research · 2020Article
- Rhythmic light flicker rescues hippocampal low gamma and protects ischemic neurons by enhancing presynaptic plasticity.Nature communications · 2020Article
- Adverse caregiving in infancy blunts neural processing of the mother.Nature communications · 2020Article
- Adaptation Modulates Spike-Phase Coupling Tuning Curve in the Rat Primary Auditory Cortex.Frontiers in systems neuroscience · 2020Article
- Mutual Information of Multiple Rhythms for EEG Signals.Frontiers in neuroscience · 2020Article
- Electrophysiological Brain Connectivity: Theory and Implementation.IEEE transactions on bio-medical engineering · 2019Article
- Inferring the direction of rhythmic neural transmission via inter-regional phase-amplitude coupling (ir-PAC).Scientific reports · 2019Article
- Introducing a Comprehensive Framework to Measure Spike-LFP Coupling.Frontiers in computational neuroscience · 2018Article
- On cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus.eLife · 2016Article
- Functional connectivity between prefrontal cortex and striatum estimated by phase locking value.Cognitive neurodynamics · 2016Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The theta-gamma cross-frequency coupling (CFC) in hippocampus was reported to reflect memory process. In this study, we measured the CFC of hippocampal local field potentials (LFPs) in a two-vessel occlusion (2VO) rat model, combined with both amplitude and phase properties and associated with short and long-term plasticity indicating the memory function. Male Wistar rats were used and a 2VO model was established. STP and LTP were recorded in hippocampal CA3-CA1 pathway after LFPs were collected in both CA3 and CA1. Based on the data of relative power spectra and phase synchronization, it suggested that both the amplitude and phase coupling of either theta or gamma rhythm were involved in modulating the neural network in 2VO rats. In order to determine whether the CFC was also implicated in neural impairment in 2VO rats, the coupling of CA3 theta-CA1 gamma was measured by both phase-phase coupling (n:m phase synchronization) and phase-amplitude coupling. The attenuated CFC strength in 2VO rats implied the impaired neural communication in the coordination of theta-gamma entraining process. Moreover, compared with modulation index (MI) a novel algorithm named cross frequency conditional mutual information (CF-CMI), was developed to focus on the coupling between theta phase and the phase of gamma amplitude. The results suggest that the reduced CFC strength probably attributed to the disruption of the phase of CA1 gamma envelop. In conclusion, it implied that the phase coupling and CFC of hippocampal theta and gamma played an important role in supporting functions of neural network. Furthermore, synaptic plasticity on CA3-CA1 pathway was reduced in line with the decreased CFC strength from CA3 to CA1. It partly supported our hypothesis that directional CFC indicator might probably be used as a measure of synaptic plasticity.
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