ArticleFrontiers in human neuroscience2013
Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 200 citations in OpenAlex.
- The effects of acute stress on episodic memory: A meta-analysis and integrative review.Psychological bulletin · 2017Pooled it
- The effects of acute stress on core executive functions: A meta-analysis and comparison with cortisol.Neuroscience and biobehavioral reviews · 2016Pooled it
- Acute stress impairs cognitive flexibility in men, not women.Stress (Amsterdam, Netherlands) · 2016Trial
- Cognitive enhancement by transcranial laser stimulation and acute aerobic exercise.Lasers in medical science · 2016Trial
- Effect of 48 h Fasting on Autonomic Function, Brain Activity, Cognition, and Mood in Amateur Weight Lifters.BioMed research international · 2016Trial
- Episodic memory impairment in Addison's disease: results from a telephonic cognitive assessment.Metabolic brain disease · 2014Trial
- Trial
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- Elevated cortisol/DHEA ratio mediates the association between symptom severity and working memory impairment in drug-naive, first-episode OCD.Frontiers in psychiatry · 2026Article
- Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder.Frontiers in molecular neuroscience · 2026Review
- Food insecurity and cognitive domains among older United States adults: Findings from the health and retirement study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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- Enhanced Performance Monitoring as a Transdiagnostic Risk Marker of the Anxiety and Obsessive-Compulsive Spectrum: The Role of Disorder Category, Clinical Status, Family Risk, and Anxiety Dimensions.Depression and anxiety · 2025Article
- Synapses mediate the effects of different types of stress on working memory: a brain-inspired spiking neural network study.Frontiers in cellular neuroscience · 2025Article
- Role of Cardiorespiratory Fitness, Aerobic, Exercise and Sports Participation in Female Cognition: A Scoping Review : Sports, Fitness, and Cognition.Sports medicine - open · 2024Article
- Ovarian hormones reduce the negative association between worry and cognitive control: A combined neural and behavioral investigation.Psychoneuroendocrinology · 2024Article
- The effects of emotional stimuli on Word retrieval in people with aphasia.Neuropsychologia · 2024Article
- Econeurobiology and brain development in children: key factors affecting development, behavioral outcomes, and school interventions.Frontiers in public health · 2024Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms and neural circuits that drive emotion and cognition are inextricably linked. Activation of the hypothalamic-pituitary-adrenal (HPA) axis as a result of stress or other causes of arousal initiates a flood of hormone and neurotransmitter release throughout the brain, affecting the way we think, decide, and behave. This review will focus on factors that influence the function of the prefrontal cortex (PFC), a brain region that governs higher-level cognitive processes and executive function. The PFC becomes markedly impaired by stress, producing measurable deficits in working memory. These deficits arise from the interaction of multiple neuromodulators, including glucocorticoids, catecholamines, and gonadal hormones; here we will discuss the non-human primate and rodent literature that has furthered our understanding of the circuitry, receptors, and signaling cascades responsible for stress-induced prefrontal dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.