ArticleFrontiers in neural circuits2013
Monocular inhibition reveals temporal and spatial changes in gene expression in the primary visual cortex of marmoset.
Article in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 23 citations in OpenAlex.
- Combinative Protein Expression of Immediate Early Genes c-Fos, Arc, and Npas4 Along Aversive and Appetitive Experience-Related Neural Networks.Hippocampus · 2025Article
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- Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024Review
- Development of ocular dominance columns across rodents and other species: revisiting the concept of critical period plasticity.Frontiers in neural circuits · 2024Review
- 'Arc'-hitecture of normal cognitive aging.Ageing research reviews · 2022Review
- The Expression Patterns of Cytochrome Oxidase and Immediate-Early Genes Show Absence of Ocular Dominance Columns in the Striate Cortex of Squirrel Monkeys Following Monocular Inactivation.Frontiers in neuroanatomy · 2021Article
- c-FOS expression in the visual system of tree shrews after monocular inactivation.The Journal of comparative neurology · 2017Article
- Expression pattern of immediate early genes in the cerebellum of D1R KO, D2R KO, and wild type mice under vestibular-controlled activity.Frontiers in cell and developmental biology · 2015Article
- Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace.Frontiers in molecular neuroscience · 2015Review
- Identification of ocular dominance domains in New World owl monkeys by immediate-early gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- mRNA expression profile of serotonin receptor subtypes and distribution of serotonergic terminations in marmoset brain.Frontiers in neural circuits · 2014Article
- DNA methylation and methyl-binding proteins control differential gene expression in distinct cortical areas of macaque monkey.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Effect of Monocular Deprivation on Rabbit Neural Retinal Cell Densities.Journal of ophthalmic & vision researchArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the time course of the expression of several activity-dependent genes evoked by visual inputs in the primary visual cortex (V1) in adult marmosets. In order to examine the rapid time course of activity-dependent gene expression, marmosets were first monocularly inactivated by tetrodotoxin (TTX), kept in darkness for two days, and then exposed to various length of light stimulation. Activity-dependent genes including HTR1B, HTR2A, whose activity-dependency were previously reported by us, and well-known immediate early genes (IEGs), c-FOS, ZIF268, and ARC, were examined by in situ hybridization. Using this system, first, we demonstrated the ocular dominance type of gene expression pattern in V1 under this condition. IEGs were expressed in columnar patterns throughout layers II-VI of all the tested monocular marmosets. Second, we showed the regulation of HTR1B and HTR2A expressions by retinal spontaneous activity, because HTR1B and HTR2A mRNA expressions sustained a certain level regardless of visual stimulation and were inhibited by a blockade of the retinal activity with TTX. Third, IEGs dynamically changed its laminar distribution from half an hour to several hours upon a stimulus onset with the unique time course for each gene. The expression patterns of these genes were different in neurons of each layer as well. These results suggest that the regulation of each neuron in the primary visual cortex of marmosets is subjected to different regulation upon the change of activities from retina. It should be related to a highly differentiated laminar structure of marmoset visual systems, reflecting the functions of the activity-dependent gene expression in marmoset V1.
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