Evidence map›Paper›PMID 23576927›Full record

ArticleThe Iowa orthopaedic journal2012

Vascular endothelial growth factor improves bone repair in a murine nonunion model.

Christian M Ogilvie, Chuanyong Lu, Ralph Marcucio, Mark Lee, Zachary Thompson, Diane Hu, Jill A Helms, Theodore Miclau

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Iowa orthopaedic journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. FDA-approved bone grafts and bone graft substitute devices in bone regeneration.Materials science & engineering. C, Materials for biological applications · 2021
    Review
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  16. Article
  17. Molecular pathogenesis of fracture nonunion.Journal of orthopaedic translation · 2018
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Christian M OgilvieDepartment of Orthopedic Surgery, Orthopaedic Trauma Institute, University of California at San Francisco, San Francisco, CA 94110, USA.
Chuanyong Lu
Ralph Marcucio
Mark Lee
Zachary Thompson
Diane Hu
Jill A Helms
Theodore Miclau
University of California, San Francisco · US

Funding

Biology of stable and non-stable fracture repairR01AR053645 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MICLAU, THEODORE · 2006 to 2010
$1.6M
ROLE OF ANGIOGENESIS IN BONE REPAIRK08AR002164 · NIAMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MICLAU, THEODORE · 2000 to 2004
$574k
NIAMS NIH HHS K08 AR002164NIAMS NIH HHS KO8-AR002164NIAMS NIH HHS R01 AR053645NIAMS NIH HHS R01-AR053645
6 · The paper itself

Abstract

objectivesVascular endothelial growth factor (VEGF) is a potent angiogenic factor that plays an important role during skeletal development and fracture healing. Previous experimental studies have shown that VEGF applied immediately after injury can stimulate bone repair in animal fracture nonunion models. However, the effectiveness of VEGF on an established fracture non-union has not been determined. the goal of this work was to test the ability of VEGF applied at a later stage on the healing of fracture nonunions.

methodsIn this study, a murine non-union model was induced by rapid distraction of a tibia osteotomy. this model exhibits radiological and histological evidence of impaired fracture healing at 7 days after the completion of distraction. VEGF (10 µg in 20 µl Pbs/day, n=10) or control (20 µl Pbs/day, n=10) was injected directly into the distraction gap through the posterior musculature on three consecutive days (7, 8, and 9 days after completing distraction). A third group of animals (n=10) with rapid distraction, but no injections, served as non-treated controls. Fracture healing was analyzed by x-ray, histology, and histomorphometry at 27 days after the last round of distraction.

resultsradiographs showed that half of the VEGF treated animals (5/10) achieved bony healing whereas the majority of Pbs treated (7/10) and non-treated controls (8/10) did not exhibit bone bridging. Histological and histomorphometric analyses demonstrated that VEGF increased, but not significantly, the amount of bone formed in the distraction gap (1.35 ± 0.35 mm(3)), compared to the saline treated (0.77 ± 0.25 mm(3), p=0.19) and non-treated animals (0.79 ± 0.23mm(3), p=0.12).

conclusionsResults from this study demonstrate that VEGF potentially promotes bone repair, warranting further research in this direction.

Indexed as

Angiogenesis Inducing AgentsAnimalsDisease Models, AnimalFracture HealingFractures, UnunitedMaleMiceTibiaTime FactorsVascular Endothelial Growth Factor AAngiogenesis Inducing AgentsVascular Endothelial Growth Factor Adelayed uniondistraction osteogenesisfracturenon-unionVascular Endothelial Growth FactorVEGF

Identifiers

PMID23576927
PMCPMC3565421
OpenAlexW1806992926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.