ArticleTheScientificWorldJournal2013
Evaluation of the antibacterial and antifungal potential of Peltophorum africanum: toxicological effect on human Chang liver cell line.
Article in TheScientificWorldJournal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Ethnomedicinal Practices of the Fabaceae Family in Tanzania: A Systematic Review.TheScientificWorldJournal · 2026Pooled it
- Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology ofPlants (Basel, Switzerland) · 2025Review
- Medicinal Uses of the Fabaceae Family in Zimbabwe: A Review.Plants (Basel, Switzerland) · 2023Review
- Identification of a novel multifunctional oxidosqualene cyclase fromSynthetic and systems biotechnology · 2022Article
- Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19.Physics and chemistry of the earth (2002) · 2022Article
- Comparative analysis of the seasonal influence on polyphenolic content, antioxidant capacity, identification of bioactive constituents and hepatoprotective biomarkers by in silico docking analysis inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Target and non-target effects ofSaudi journal of biological sciences · 2021Article
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- Antifungal, anti-oxidant activity and cytotoxicity of South African medicinal plants against mycotoxigenic fungi.Heliyon · 2018Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We assessed the in vitro antimicrobial activity of Peltophorum africanum by means of the agar well and macrodilution methods. The toxicity on a normal human liver cell (Chang liver cell) was determined using the CellTiter-Blue cell viability assay, and the compounds contained in the fractions were identified using GC-MS. Zone diameter of inhibition of the extract ranged from 12.5 ± 0.7 to 32 ± 2.8 mm for bacteria and from 7.5 ± 0.7 to 26.4 ± 3.4 mm for yeast. Marked activity of the extract was observed against Plesiomonas shigelloides ATCC 51903, with MIC and MLC values of 0.15625 and 0.3125 mg/mL, respectively. The extract was both bactericidal (MIC(index) ≤ 2) and bacteriostatic/fungistatic (MIC(index) > 2) in activity. Lethal dose at 50 (LD50) showed 82.64 ± 1.40 degree of toxicity at 24 hrs, and 95 percentile of cell death dose activity ranged from log 3.12 ± 0.01 to 4.59 ± 0.03. The activity of the eight fractions tested ranged from 1.0 ± 0.5 to 3.7 ± 1.6 mg/mL (IC50) and from 2.1 ± 0.8 to 6.25 ± 0 mg/mL (IC90). The extract was toxic to human Chang liver cell lines.
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Registered trials
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