ReviewDialogues in clinical neuroscience2013
Chronic depression as a model disease for cerebral aging.
Review in Dialogues in clinical neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Deep brain stimulation for treatment-resistant depression: systematic review of clinical outcomes.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Pooled it
- Has Deep Brain Stimulation Shown Its Full Potential in Treatment-Resistant Depression? A Scoping Review.Biological psychiatry global open science · 2026Review
- Neuroimmune Interactions in Stress and Depression: Exploring the Molecular and Cellular Mechanisms within the Neuroinflammation-depression Nexus.Current medicinal chemistry · 2026Review
- Wearable neurofeedback acceptance model for students' stress and anxiety management in academic settings.PloS one · 2024Article
- A Review on Integrated ZnO-Based SERS Biosensors and Their Potential in Detecting Biomarkers of Neurodegenerative Diseases.Biosensors · 2023Review
- Alzheimer's disease and depression in the elderly: A trajectory linking gut microbiota and serotonin signaling.Frontiers in psychiatry · 2022Review
- Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice.Molecular neurobiology · 2018Article
- Identification of the stria medullaris thalami using diffusion tensor imaging.NeuroImage. Clinical · 2016Article
- The neuroscience of depression: implications for assessment and intervention.Behaviour research and therapy · 2014Review
- Aging and neuroplasticity.Dialogues in clinical neuroscience · 2013Article
- Accelerated aging in major depression: the role of nitro-oxidative stress.Oxidative medicine and cellular longevity · 2013Review
- Valproic acid withdrawal ameliorates impairments of hippocampal-spatial working memory and neurogenesis.Journal of Zhejiang University. Science. BArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conceptualizations of the underlying neurobiology of major depression have changed their focus from dysfunctions of neurotransmission to dysfunctions of neurogenesis and neuroprotection. The "neurogenesis hypothesis of depression" posits that changes in the rate of neurogenesis are the underlying mechanism in the pathology and treatment of major depression. Stress, neuroinflammation, dysfunctional insulin regulation, oxidative stress, and alterations in neurotrophic factors possibly contribute to the development of depression. The influence of antidepressant therapies, namely pharmacotherapy and neuroprotectants, on cellular plasticity are summarized. A dysfunction of complex neuronal networks as a consequence of neural degeneration in neuropsychiatric diseases has led to the application of deep brain stimulation. We discuss the way depression seen in the light of the neurogenesis hypothesis can be used as a model disease for cerebral aging. A common pathological mechanism in depression and cerebral aging-a dysfunction of neuroprotection and neurogenesis-is discussed. This has implications for new treatment methods.
Indexed as
Identifiers
23576891PMC3622471W104529366What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.