Evidence map›Paper›PMID 23576850›Full record

ReviewMediators of inflammation2013

The role of cell surface architecture of lactobacilli in host-microbe interactions in the gastrointestinal tract.

Ranjita Sengupta, Eric Altermann, Rachel C Anderson, Warren C McNabb, Paul J Moughan, Nicole C Roy

Open access · goldAbstract readReview
In one paragraph

Review in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed
27.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 275 citations in OpenAlex.

  1. Gut microbes · 2026
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  9. Secretome Profiling ofAntibiotics (Basel, Switzerland) · 2026
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  15. Exploring the interplay betweenThe veterinary quarterly · 2025
    Review
  16. Review
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  18. Biodegradation of Cholesterol byMicroorganisms · 2025
    Article
  19. Internalization ofMicroorganisms · 2025
    Article
  20. Review

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ranjita SenguptaFood Nutrition & Health Team, Food & Bio-Based Products Group, Palmerston North 4442, New Zealand.
Eric Altermann
Rachel C Anderson
Warren C McNabb
Paul J Moughan
Nicole C Roy
Riddet Institute · NZAgResearch · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactobacillus species can exert health promoting effects in the gastrointestinal tract (GIT) through many mechanisms, which include pathogen inhibition, maintenance of microbial balance, immunomodulation, and enhancement of the epithelial barrier function. Different species of the genus Lactobacillus can evoke different responses in the host, and not all strains of the same species can be considered beneficial. Strain variations may be related to diversity of the cell surface architecture of lactobacilli and the bacteria's ability to express certain surface components or secrete specific compounds in response to the host environment. Lactobacilli are known to modify their surface structures in response to stress factors such as bile and low pH, and these adaptations may help their survival in the face of harsh environmental conditions encountered in the GIT. In recent years, multiple cell surface-associated molecules have been implicated in the adherence of lactobacilli to the GIT lining, immunomodulation, and protective effects on intestinal epithelial barrier function. Identification of the relevant bacterial ligands and their host receptors is imperative for a better understanding of the mechanisms through which lactobacilli exert their beneficial effects on human health.

Indexed as

Bacterial AdhesionGastrointestinal TractHumansLactobacillusProbiotics

Identifiers

PMID23576850
PMCPMC3610365
OpenAlexW2087805542

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.