ArticleProceedings of the National Academy of Sciences of the United States of America2013
Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Novel tissue mechanics-guided cellular flows drive the formation of feather follicles.The EMBO journal · 2026Article
- Roles of K-channel activity in feather bud morphogenesis.Developmental biology · 2026Article
- Regulation of feather length: FGF/IGF signaling and NOTCH/YAP modulation of progenitor cell topology.Science advances · 2025Article
- Gap junctions in Turing-type periodic feather pattern formation.PLoS biology · 2024Article
- A Wnt10a-Notch signaling axis controls Hertwig's epithelial root sheath cell behaviors during root furcation patterning.International journal of oral science · 2024Article
- Article
- Using Avian Skin Explants to Study Tissue Patterning and Organogenesis.Journal of visualized experiments : JoVE · 2023Article
- Global feather orientations changed by electric current.iScience · 2021Article
- Integrating Bioelectrical Currents and CaBioelectricity · 2020Review
- Emulating the early phases of human tooth development in vitro.Scientific reports · 2019Article
- Morpho-regulation in diverse chicken feather formation: Integrating branching modules and sex hormone-dependent morpho-regulatory modules.Development, growth & differentiation · 2019Article
- Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks.Nature communications · 2018Article
- Differential network as an indicator of osteoporosis with network entropy.Experimental and therapeutic medicine · 2018Article
- Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling.Nature communications · 2018Article
- Article
- Integrative analysis of the Pekin duck (Anas anas) MicroRNAome during feather follicle development.BMC developmental biology · 2017Article
- Tissue patterning and cellular mechanics.The Journal of cell biology · 2015Review
- Transcriptomic analyses of regenerating adult feathers in chicken.BMC genomics · 2015Article
- Deciphering principles of morphogenesis from temporal and spatial patterns on the integument.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Evolution and functional significance of derived sternal ossification patterns in ornithothoracine birds.Journal of evolutionary biology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
How organs are shaped to specific forms is a fundamental issue in developmental biology. To address this question, we used the repetitive, periodic pattern of feather morphogenesis on chicken skin as a model. Avian feathers within a single tract extend from dome-shaped primordia to thin conical structures with a common axis of orientation. From a systems biology perspective, the process is precise and robust. Using tissue transplantation assays, we demonstrate that a "zone of polarizing activity," localized in the posterior feather bud, is necessary and sufficient to mediate the directional elongation. This region contains a spatially well-defined nuclear β-catenin zone, which is induced by wingless-int (Wnt)7a protein diffusing in from posterior bud epithelium. Misexpressing nuclear β-catenin randomizes feather polarity. This dermal nuclear β-catenin zone, surrounded by Notch1 positive dermal cells, induces Jagged1. Inhibition of Notch signaling disrupts the spatial configuration of the nuclear β-catenin zone and leads to randomized feather polarity. Mathematical modeling predicts that lateral inhibition, mediated by Notch signaling, functions to reduce Wnt7a gradient variations and fluctuations to form the sharp boundary observed for the dermal β-catenin zone. This zone is also enriched for nonmuscle myosin IIB. Suppressing nonmuscle myosin IIB disrupts directional cell rearrangements and abolishes feather bud elongation. These data suggest that a unique molecular module involving chemical-mechanical coupling converts a pliable chemical gradient to a precise domain, ready for subsequent mechanical action, thus defining the position, boundary, and duration of localized morphogenetic activity that molds the shape of growing organs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.