ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2013
Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
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- Cell type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling.bioRxiv : the preprint server for biology · 2026Article
- Neuron-derived neurotrophic factor promotes the differentiation of intramuscular and subcutaneous adipocytes in goat.Animal biotechnology · 2024Article
- Cerebrospinal fluid proteomic signatures are associated with symptom severity of first-episode psychosis.Journal of psychiatric research · 2024Article
- A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling.Communications biology · 2024Article
- Serum Neudesin Levels in Obese AdolescentsJournal of clinical research in pediatric endocrinology · 2022Article
- Review of Novel Potential Insulin Resistance Biomarkers in PCOS Patients-The Debate Is Still Open.International journal of environmental research and public health · 2022Review
- Proteomics analysis of the hypothalamus in spontaneously hypertensive rats treated with twirling reinforcing manipulation, twirling reducing manipulation or electroacupuncture.Experimental and therapeutic medicine · 2021Article
- Effect of Neudesin Neurotrophic Factor on Differentiation of Bovine Preadipocytes and Myoblasts in a Co-Culture System.Animals : an open access journal from MDPI · 2020Article
- Neudesin Neurotrophic Factor Promotes Bovine Preadipocyte Differentiation and Inhibits Myoblast Myogenesis.Animals : an open access journal from MDPI · 2019Article
- Maternal Obesity Alters Neurotrophin-Associated MAPK Signaling in the Hypothalamus of Male Mouse Offspring.Frontiers in neuroscience · 2019Article
- Neudesin in obesity and type 2 diabetes mellitus: the effect of acute fasting and weight reducing interventions.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Adult Hippocampal Neurogenesis Modulation by the Membrane-Associated Progesterone Receptor Family Member Neudesin.Frontiers in cellular neuroscience · 2018Article
- Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity.Scientific reports · 2015Article
- Neudesin as a unique secreted protein with multi-functional roles in neural functions, energy metabolism, and tumorigenesis.Frontiers in molecular biosciences · 2015Review
- Dynamic and extensive metabolic state-dependent regulation of cytokine expression and circulating levels.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Seasonal oscillation of liver-derived hibernation protein complex in the central nervous system of non-hibernating mammals.The Journal of experimental biology · 2014Article
- Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus.Cell reports · 2014Article
- C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight.The Journal of biological chemistry · 2014Article
- Drug delivery systems, CNS protection, and the blood brain barrier.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Disruption of finely coordinated neuropeptide signals in the hypothalamus can result in altered food intake and body weight. We identified neuron-derived neurotrophic factor (NENF) as a novel secreted protein through a large-scale screen aimed at identifying novel secreted hypothalamic proteins that regulate food intake. We observed robust Nenf expression in hypothalamic nuclei known to regulate food intake, and its expression was altered under the diet-induced obese (DIO) condition relative to the fed state. Hypothalamic Nenf mRNA was regulated by brain-derived neurotrophic factor (BDNF) signaling, itself an important regulator of appetite. Delivery of purified recombinant BDNF into the lateral cerebral ventricle decreased hypothalamic Nenf expression, while pharmacological inhibition of trkB signaling increased Nenf mRNA expression. Furthermore, recombinant NENF administered via an intracerebroventricular cannula decreased food intake and body weight and increased hypothalamic Pomc and Mc4r mRNA expression. Importantly, the appetite-suppressing effect of NENF was abrogated in obese mice fed a high-fat diet, demonstrating a diet-dependent modulation of NENF function. We propose the existence of a regulatory circuit involving BDNF, NENF, and melanocortin signaling. Our study validates the power of using an integrated experimental and bioinformatic approach to identify novel CNS-derived proteins with appetite-modulating function and reveals NENF as an important central modulator of food intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.