Evidence map›Paper›PMID 23576418›Full record

ArticleJournal of biophotonics2014

M13 virus based detection of bacterial infections in living hosts.

Neelkanth M Bardhan, Debadyuti Ghosh, Angela M Belcher

Abstract read
In one paragraph

Article in Journal of biophotonics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Real-TimeACS biomaterials science & engineering · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Recent Progress in the Molecular Imaging of Tumor-Treating Bacteria.Nuclear medicine and molecular imaging · 2021
    Review
  8. Article
  9. Review
  10. Review
  11. Using viruses as nanomedicines.British journal of pharmacology · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Neelkanth M BardhanDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; The David H. Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology, Cambridge, MA, USA.
Debadyuti Ghosh
Angela M Belcher

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Michael Birnbaum · 1985 to 2026
$93.9M
The Development of Clinical Grade, Targeted Magnetic NanoparticlesU54CA151884 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2010 to 2014
$11.3M
NCI NIH HHS 5-U54-CA151884-03NCI NIH HHS P30 CA014051NCI NIH HHS U54 CA151884
6 · The paper itself

Abstract

We report a first method for using M13 bacteriophage as a multifunctional scaffold for optically imaging bacterial infections in vivo. We demonstrate that M13 virus conjugated with hundreds of dye molecules (M13-Dye) can target and distinguish pathogenic infections of F-pili expressing and F-negative strains of E. coli. Further, in order to tune this M13-Dye complex suitable for targeting other strains of bacteria, we have used a 1-step reaction for creating an anti-bacterial antibody-M13-Dye probe. As an example, we show anti-S. aureus-M13-Dye able to target and image infections of S. aureus in living hosts, with a 3.7× increase in fluorescence over background.

Indexed as

AnimalsBacteriaBacterial InfectionsBacteriophage M13FemaleFluorescent DyesMiceMolecular ImagingFluorescent Dyesbacterial infectionsfluorescent dyeM13 bacteriophageoptical imaging

Identifiers

PMID23576418
PMCPMC3989466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.