ArticleGenome biology and evolution2013
Rapid evolution of Beta-keratin genes contribute to phenotypic differences that distinguish turtles and birds from other reptiles.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Immunohistochemical study of α-keratin, loricrin, filaggrin-like protein, and transglutaminase-1 expression in orthokeratinized and parakeratinized epithelium of the tongue of domestic goose (Anser anser f. domestica) during embryonic development.Histochemistry and cell biology · 2026Article
- Structural and Functional Elements of the Epidermal Appendages in Birds and Reptiles: Conformations and Modes of Assembly of the Constituent β-Filaments and Keratin Intermediate Filaments (IF).Sub-cellular biochemistry · 2026Review
- Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair and Other Cornified Epithelial Structures.Animals : an open access journal from MDPI · 2025Review
- Insights into the adaptive evolution of chromosome and essential traits through chromosome-level genome assembly ofiScience · 2024Article
- Development-Associated Genes of the Epidermal Differentiation Complex (EDC).Journal of developmental biology · 2024Review
- The Story of the Finest Armor: Developmental Aspects of Reptile Skin.Journal of developmental biology · 2023Review
- A new haplotype-resolved turkey genome to enable turkey genetics and genomics research.GigaScience · 2022Article
- Making region-specific integumentary organs in birds: evolution and modifications.Current opinion in genetics & development · 2021Review
- Cell proliferation, adhesion, and differentiation of keratinocytes in the developing beak and egg-tooth of the turtle Emydura macquarii.Protoplasma · 2020Article
- Corneous beta proteins of the epidermal differentiation complex (EDC) form large part of the corneous material of claws and rhamphothecae in turtles.Protoplasma · 2020Article
- Copy Number Variation Mapping and Genomic Variation of Autochthonous and Commercial Turkey Populations.Frontiers in genetics · 2019Article
- Comparative Analysis of Epidermal Differentiation Genes of Crocodilians Suggests New Models for the Evolutionary Origin of Avian Feather Proteins.Genome biology and evolution · 2018Article
- Biochemistry and adaptive colouration of an exceptionally preserved juvenile fossil sea turtle.Scientific reports · 2017Article
- Review: cornification, morphogenesis and evolution of feathers.Protoplasma · 2017Review
- Comparative Genomics Identifies Epidermal Proteins Associated with the Evolution of the Turtle Shell.Molecular biology and evolution · 2016Article
- Topographical mapping of α- and β-keratins on developing chicken skin integuments: Functional interaction and evolutionary perspectives.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Deciphering principles of morphogenesis from temporal and spatial patterns on the integument.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Feather development genes and associated regulatory innovation predate the origin of Dinosauria.Molecular biology and evolution · 2015Article
- Dynamic evolution of the alpha (α) and beta (β) keratins has accompanied integument diversification and the adaptation of birds into novel lifestyles.BMC evolutionary biology · 2014Article
- Genomic organization, transcriptomic analysis, and functional characterization of avian α- and β-keratins in diverse feather forms.Genome biology and evolution · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Sequencing of vertebrate genomes permits changes in distinct protein families, including gene gains and losses, to be ascribed to lineage-specific phenotypes. A prominent example of this is the large-scale duplication of beta-keratin genes in the ancestors of birds, which was crucial to the subsequent evolution of their beaks, claws, and feathers. Evidence suggests that the shell of Pseudomys nelsoni contains at least 16 beta-keratins proteins, but it is unknown whether this is a complete set and whether their corresponding genes are orthologous to avian beak, claw, or feather beta-keratin genes. To address these issues and to better understand the evolution of the turtle shell at a molecular level, we surveyed the diversity of beta-keratin genes from the genome assemblies of three turtles, Chrysemys picta, Pelodiscus sinensis, and Chelonia mydas, which together represent over 160 Myr of chelonian evolution. For these three turtles, we found 200 beta-keratins, which indicate that, as for birds, a large expansion of beta-keratin genes in turtles occurred concomitantly with the evolution of a unique phenotype, namely, their plastron and carapace. Phylogenetic reconstruction of beta-keratin gene evolution suggests that separate waves of gene duplication within a single genomic location gave rise to scales, claws, and feathers in birds, and independently the scutes of the shell in turtles.
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