Evidence map›Paper›PMID 23576159›Full record

ArticleStatistics in medicine2014

Joint modeling compliance and outcome for causal analysis in longitudinal studies.

Xin Gao, Gregory K Brown, Michael R Elliott

Abstract read
In one paragraph

Article in Statistics in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xin GaoDepartment of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109, U.S.A.
Gregory K Brown
Michael R Elliott

Funding

COGNITIVE THERAPY FOR THE PREVENTION OF SUICIDEP20MH071905 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BECK, AARON T · 2004 to 2008
$2.8M
POLY (ADP RIBOSE) SYNTHETASE AND PEROXYNITRITE INDUCED CR01GM060915 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI SZABO, CSABA · 1999 to 2009
$1.9M
Latexin's role in parsing stem cellsR01HD060915 · NICHD · UNIVERSITY OF KENTUCKY · PI VAN ZANT, GARY · 2009 to 2012
$1.4M
Causal Methods for Mediation and InteractionR01MH078016 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI JOFFE, MARSHALL M · 2007 to 2010
$1.3M
EARLY COGNITIVE INTERVENTION FOR SUICIDE ATTEMPTERSR01MH060915 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BECK, AARON T · 2000 to 2004
$1.1M
NICHD NIH HHS R01 HD060915NIGMS NIH HHS R01 GM060915NIMH NIH HHS P20 MH071905NIMH NIH HHS P20 MH71905NIMH NIH HHS R01 MH060915NIMH NIH HHS R01 MH078016NIMH NIH HHS R01 MH60915PHS HHS R37 CCR316866
6 · The paper itself

Abstract

This article discusses joint modeling of compliance and outcome for longitudinal studies when noncompliance is present. We focus on two-arm randomized longitudinal studies in which subjects are randomized at baseline, treatment is applied repeatedly over time, and compliance behaviors and clinical outcomes are measured and recorded repeatedly over time. In the proposed Markov compliance and outcome model, we use the potential outcome framework to define pre-randomization principal strata from the joint distribution of compliance under treatment and control arms, and estimate the effect of treatment within each principal strata. Besides the causal effect of the treatment, our proposed model can estimate the impact of the causal effect of the treatment at a given time on future compliance. Bayesian methods are used to estimate the parameters. The results are illustrated using a study assessing the effect of cognitive behavior therapy on depression. A simulation study is used to assess the repeated sampling properties of the proposed model.

Indexed as

CausalityLongitudinal StudiesPatient ComplianceAdultBayes TheoremCognitive Behavioral TherapyComputer SimulationDepressionFemaleHumansMaleMarkov ChainsMiddle AgedPsychiatric Status Rating ScalesRandomized Controlled Trials as TopicSuicide, Attemptedcausal inferencenoncompliancepotential outcomeprincipal stratification

Identifiers

PMID23576159
PMCPMC3788835

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.