ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Cortical cholinergic input is required for normal auditory perception and experience-dependent plasticity in adult ferrets.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Partial maintenance of auditory-based cognitive training benefits in older adults.Neuropsychologia · 2014Trial
- Immersive audiomotor game play enhances neural and perceptual salience of weak signals in noise.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Article
- Neural processing in the primary auditory cortex following cholinergic lesions of the basal forebrain in ferrets.Hearing research · 2024Article
- Cholinergic modulation in the vertebrate auditory pathway.Frontiers in cellular neuroscience · 2024Review
- Cholinergic modulation of sensory perception and plasticity.Neuroscience and biobehavioral reviews · 2023Review
- Implementation of Manual and Automated Water Regulation for Rats (Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- When and How Does the Auditory Cortex Influence Subcortical Auditory Structures? New Insights About the Roles of Descending Cortical Projections.Frontiers in neuroscience · 2021Review
- Cholinergic Projections From the Pedunculopontine Tegmental Nucleus Contact Excitatory and Inhibitory Neurons in the Inferior Colliculus.Frontiers in neural circuits · 2020Article
- Silencing cortical activity during sound-localization training impairs auditory perceptual learning.Nature communications · 2019Article
- Development, organization and plasticity of auditory circuits: Lessons from a cherished colleague.The European journal of neuroscience · 2019Review
- Computational Neural Modeling of Auditory Cortical Receptive Fields.Frontiers in computational neuroscience · 2019Article
- Cholinergic Hypofunction in Presbycusis-Related Tinnitus With Cognitive Function Impairment: Emerging Hypotheses.Frontiers in aging neuroscience · 2018Article
- Recent advances in understanding the auditory cortex.F1000Research · 2018Review
- Basal Forebrain Cholinergic-Auditory Cortical Network: Primary Versus Nonprimary Auditory Cortical Areas.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Muscarinic acetylcholine receptors control baseline activity and Hebbian stimulus timing-dependent plasticity in fusiform cells of the dorsal cochlear nucleus.Journal of neurophysiology · 2017Article
- The Input-Output Relationship of the Cholinergic Basal Forebrain.Cell reports · 2017Article
- Models of Acetylcholine and Dopamine Signals Differentially Improve Neural Representations.Frontiers in computational neuroscience · 2017Article
- Cell-Specific Cholinergic Modulation of Excitability of Layer 5B Principal Neurons in Mouse Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Relating approach-to-target and detection tasks in animal psychoacoustics.Behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The nucleus basalis (NB) in the basal forebrain provides most of the cholinergic input to the neocortex and has been implicated in a variety of cognitive functions related to the processing of sensory stimuli. However, the role that cortical acetylcholine release plays in perception remains unclear. Here we show that selective loss of cholinergic NB neurons that project to the cortex reduces the accuracy with which ferrets localize brief sounds and prevents them from adaptively reweighting auditory localization cues in response to chronic occlusion of one ear. Cholinergic input to the cortex was disrupted by making bilateral injections of the immunotoxin ME20.4-SAP into the NB. This produced a substantial loss of both p75 neurotrophin receptor (p75(NTR))-positive and choline acetyltransferase-positive cells in this region and of acetylcholinesterase-positive fibers throughout the auditory cortex. These animals were significantly impaired in their ability to localize short broadband sounds (40-500 ms in duration) in the horizontal plane, with larger cholinergic cell lesions producing greater performance impairments. Although they localized longer sounds with normal accuracy, their response times were significantly longer than controls. Ferrets with cholinergic forebrain lesions were also less able to relearn to localize sound after plugging one ear. In contrast to controls, they exhibited little recovery of localization performance after behavioral training. Together, these results show that cortical cholinergic inputs contribute to the perception of sound source location under normal hearing conditions and play a critical role in allowing the auditory system to adapt to changes in the spatial cues available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.