ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Odor-specific, olfactory marker protein-mediated sparsening of primary olfactory input to the brain after odor exposure.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Target-dependent routing of sensory information in the olfactory system.Communications biology · 2026Article
- The Role of the Stimulus in Olfactory Plasticity.Brain sciences · 2023Review
- Article
- NIH Workshop Report: sensory nutrition and disease.The American journal of clinical nutrition · 2021Article
- The functional relevance of olfactory marker protein in the vertebrate olfactory system: a never-ending story.Cell and tissue research · 2021Review
- Amyotrophic Lateral Sclerosis Is Accompanied by Protein Derangements in the Olfactory Bulb-Tract Axis.International journal of molecular sciences · 2020Article
- Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map.Nature communications · 2018Article
- Mild Fluid Percussion Injury Induces Diffuse Axonal Damage and Reactive Synaptic Plasticity in the Mouse Olfactory Bulb.Neuroscience · 2018Article
- Persistent, generalized hypersensitivity of olfactory bulb interneurons after olfactory fear generalization.Neurobiology of learning and memory · 2017Article
- Intranasal application of glucocorticoid alleviates olfactory dysfunction in mice with allergic rhinitis.Experimental and therapeutic medicine · 2017Article
- Activity Patterns Elicited by Airflow in the Olfactory Bulb and Their Possible Functions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons.The Journal of comparative neurology · 2017Article
- Neuromodulation in Chemosensory Pathways.Chemical senses · 2017Review
- Poor human olfaction is a 19th-century myth.Science (New York, N.Y.) · 2017Review
- Differences in peripheral sensory input to the olfactory bulb between male and female mice.Scientific reports · 2017Article
- Amygdalar Gating of Early Sensory Processing through Interactions with Locus Coeruleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Axonal ribosomes and mRNAs associate with fragile X granules in adult rodent and human brains.Human molecular genetics · 2017Article
- Properties of an optogenetic model for olfactory stimulation.The Journal of physiology · 2016Article
- Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure in Adult Mice.Chemical senses · 2016Article
- Associative learning and sensory neuroplasticity: how does it happen and what is it good for?Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Long-term plasticity in sensory systems is usually conceptualized as changing the interpretation of the brain of sensory information, not an alteration of how the sensor itself responds to external stimuli. However, here we demonstrate that, in the adult mouse olfactory system, a 1-week-long exposure to an artificially odorized environment narrows the range of odorants that can induce neurotransmitter release from olfactory sensory neurons (OSNs) and reduces the total transmitter release from responsive neurons. In animals heterozygous for the olfactory marker protein (OMP), this adaptive plasticity was strongest in the populations of OSNs that originally responded to the exposure odorant (an ester) and also observed in the responses to a similar odorant (another ester) but had no effect on the responses to odorants dissimilar to the exposure odorant (a ketone and an aldehyde). In contrast, in OMP knock-out mice, odorant exposure reduced the number and amplitude of OSN responses evoked by all four types of odorants equally. The effect of this plasticity is to preferentially sparsen the primary neural representations of common olfactory stimuli, which has the computational benefit of increasing the number of distinct sensory patterns that could be represented in the circuit and might thus underlie the improvements in olfactory discrimination often observed after odorant exposure (Mandairon et al., 2006a). The absence of odorant specificity in this adaptive plasticity in OMP knock-out mice suggests a potential role for this protein in adaptively reshaping OSN responses to function in different environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.