ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Regulation of spatial selectivity by crossover inhibition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Harmonics added to a flickering light can upset the balance between ON and OFF pathways to produce illusory colors.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- A standard model for the vertebrate retina.Vision research · 2026Article
- Spatially local inhibition and synaptic plasticity together enable dynamic, context-dependent integration of parallel sensory pathways.Cell reports · 2026Article
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- Dynamic Nonlinear Spatial Integrations on Encoding Contrasting Stimuli of Tectal Neurons.Animals : an open access journal from MDPI · 2024Article
- Diversity of Ganglion Cell Responses to Saccade-Like Image Shifts in the Primate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Functional architecture of neural circuits for leg proprioception in Drosophila.Current biology : CB · 2021Article
- A novel theoretical framework for simultaneous measurement of excitatory and inhibitory conductances.PLoS computational biology · 2021Article
- Predictive encoding of motion begins in the primate retina.Nature neuroscience · 2021Article
- Article
- Wide-field amacrine cell inputs to ON parasol ganglion cells in macaque retina.The Journal of comparative neurology · 2020Article
- Article
- Article
- Article
- Neural Mechanisms Mediating Motion Sensitivity in Parasol Ganglion Cells of the Primate Retina.Neuron · 2018Article
- A Pixel-Encoder Retinal Ganglion Cell with Spatially Offset Excitatory and Inhibitory Receptive Fields.Cell reports · 2018Article
- General features of inhibition in the inner retina.The Journal of physiology · 2017Review
- Corticogeniculate feedback sharpens the temporal precision and spatial resolution of visual signals in the ferret.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
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Authors and funding
2 authors.
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Abstract
Signals throughout the nervous system diverge into parallel excitatory and inhibitory pathways that later converge on downstream neurons to control their spike output. Converging excitatory and inhibitory synaptic inputs can exhibit a variety of temporal relationships. A common motif is feedforward inhibition, in which an increase (decrease) in excitatory input precedes a corresponding increase (decrease) in inhibitory input. The delay of inhibitory input relative to excitatory input originates from an extra synapse in the circuit shaping inhibitory input. Another common motif is push-pull or "crossover" inhibition, in which increases (decreases) in excitatory input occur together with decreases (increases) in inhibitory input. Primate On midget ganglion cells receive primarily feedforward inhibition and On parasol cells receive primarily crossover inhibition; this difference provides an opportunity to study how each motif shapes the light responses of cell types that play a key role in visual perception. For full-field stimuli, feedforward inhibition abbreviated and attenuated responses of On midget cells, while crossover inhibition, though plentiful, had surprisingly little impact on the responses of On parasol cells. Spatially structured stimuli, however, could cause excitatory and inhibitory inputs to On parasol cells to increase together, adopting a temporal relation very much like that for feedforward inhibition. In this case, inhibitory inputs substantially abbreviated a cell's spike output. Thus inhibitory input shapes the temporal stimulus selectivity of both midget and parasol ganglion cells, but its impact on responses of parasol cells depends strongly on the spatial structure of the light inputs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.