Evidence map›Paper›PMID 23575742›Full record

SynthesisNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013

The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: a meta-analysis.

Sara Shahrestani, Andrew H Kemp, Adam J Guastella

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06945926 (The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery：Two-Stage Designs for Phase II Clinical Trials), which is not on this map. Cited by 113 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 6 pooled it
31.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06945926 phase2completednot on this mapstarted 2025, after this paper: background citation

The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery：Two-Stage Designs for Phase II Clinical Trials

TypeinterventionalSponsorZhejiang UniversityRan2025 to 2026Enrolled227ConditionsCervical Spinal Stenosis, Thoracic Spinal Stenosis, Lumbar Spinal Stenosis, Rotator Cuff InjuryArmsoxytocin nasal spray
3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 6 syntheses or guidelines pooled it, 287 citations in OpenAlex.

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  7. Effects of intranasal oxytocin on fear extinction learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sara ShahrestaniBrain and Mind Research Institute, The University of Sydney, Camperdown, NSW, Australia.
Andrew H Kemp
Adam J Guastella
University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many studies have highlighted the potential of oxytocin (OT) to enhance facial affect recognition in healthy humans. However, inconsistencies have emerged with regard to the influence of OT on the recognition of specific emotional expressions (happy, angry, fear, surprise, disgust, and sadness). In this study, we conducted a meta-analysis of seven studies comprising 381 research participants (71 females) examining responses to the basic emotion types to assess whether OT enhances the recognition of emotion from human faces and whether this was influenced by the emotion expression and exposure time of the face. Results showed that intranasal OT administration enhances emotion recognition of faces overall, with a Hedges g effect size of 0.29. When analysis was restricted to facial expression types, significant effects of OT on recognition accuracy were specifically found for the recognition of happy and fear faces. We also found that effect sizes increased to moderate when exposure time of the photograph was restricted to early phase recognition (< 300 ms) for happy and angry faces, or later phase recognition for fear faces (> 300 ms). The results of the meta-analysis further suggest that OT has potential as a treatment to improve the recognition of emotion in faces, allowing individuals to improve their insight into the intentions, desires, and mental states of others.

Indexed as

Administration, IntranasalEmotionsFacial ExpressionHumansNeuropeptidesOxytocinPhotic StimulationRandomized Controlled Trials as TopicRecognition, PsychologyTime FactorsNeuropeptidesOxytocin

Identifiers

PMID23575742
PMCPMC3746698
OpenAlexW1965231812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.