ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2013
Pausing for thought: disrupting the early transcription elongation checkpoint leads to developmental defects and tumourigenesis.
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- RN7SK small nuclear RNA controls bidirectional transcription of highly expressed gene pairs in skin.Nature communications · 2021Article
- Motif 1 Binding Protein suppresses wingless to promote eye fate in Drosophila.Scientific reports · 2020Article
- Promoter Proximal Pausing Limits Tumorous Growth Induced by the Yki Transcription Factor inGenetics · 2020Article
- Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation.Genes & development · 2019Review
- Recent insights into Groucho co-repressor recruitment and function.Transcription · 2015Article
- The Groucho co-repressor is primarily recruited to local target sites in active chromatin to attenuate transcription.PLoS genetics · 2014Article
- Pleiohomeotic interacts with the core transcription elongation factor Spt5 to regulate gene expression in Drosophila.PloS one · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Factors affecting transcriptional elongation have been characterized extensively in in vitro, single cell (yeast) and cell culture systems; however, data from the context of multicellular organisms has been relatively scarce. While studies in homogeneous cell populations have been highly informative about the underlying molecular mechanisms and prevalence of polymerase pausing, they do not reveal the biological impact of perturbing this regulation in an animal. The core components regulating pausing are expressed in all animal cells and are recruited to the majority of genes, however, disrupting their function often results in discrete phenotypic effects. Mutations in genes encoding key regulators of transcriptional pausing have been recovered from several genetic screens for specific phenotypes or interactions with specific factors in mice, zebrafish and flies. Analysis of these mutations has revealed that control of transcriptional pausing is critical for a diverse range of biological pathways essential for animal development and survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.