ArticleVirology journal2013
Structural analysis and epitope prediction of HCV E1 protein isolated in Pakistan: an in-silico approach.
Article in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- HCV immunodominant peptide mapping reveals unique HLA-A*02-restricted signatures: insights for CD8Immunogenetics · 2025Article
- Immunoinformatics approach for predicting epitopes in HN and F proteins of Porcine rubulavirus.PloS one · 2020Article
- Epitope-Based Peptide Vaccine against Glycoprotein G of NipahJournal of immunology research · 2020Article
- A multiepitopic theoretical fusion construct based on in-silico epitope screening of known vaccine candidates for protection against wide range of enterobacterial pathogens.Human immunology · 2019Article
- Structural and Epitope Analysis (T- and B-Cell Epitopes) of Hepatitis C Virus (HCV) Glycoproteins: AnJournal of clinical and experimental hepatology · 2018Article
- Peptide vaccine against chikungunya virus: immuno-informatics combined with molecular docking approach.Journal of translational medicine · 2018Article
- Progress and challenges in predicting protein interfaces.Briefings in bioinformatics · 2016Review
- A comprehensive immunoinformatics and target site study revealed the corner-stone toward Chikungunya virus treatment.Molecular immunology · 2015Article
- Diagnostic tests for hepatitis C: recent trends in electrochemical immunosensor and genosensor analysis.World journal of gastroenterology · 2014Review
- HCV Envelope protein 2 sequence comparison of Pakistani isolate and In-silico prediction of conserved epitopes for vaccine development.Journal of translational medicine · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
backgroundHCV infection is a major health problem causing acute and chronic hepatitis. HCV E1 protein is a transmembrane protein that is involved in viral attachment and therefore, can serve as an important target for vaccine development. Consequently, this study was designed to analyze the HCV E1 protein sequence isolated in Pakistan to find potential conserved epitopes/antigenic determinants.
resultsHCV E1 protein isolated in Pakistan was analyzed using various bio-informatics and immuno-informatics tools including sequence and structure tools. A total of four antigenic B cell epitopes, 5 MHC class I binding peptides and 5 MHC class II binding peptides were predicted. Best designed epitopes were subjected to conservation analyses with other countries.
conclusionThe study was conducted to predict antigenic determinants/epitopes of HCV E1 protein of genotype 3a along with the 3D protein modeling. The study revealed potential B-cell and T-cell epitopes that can raise the desired immune response against HCV E1 protein isolated in Pakistan. Conservation analysis can be helpful in developing effective vaccines against HCV and thus limiting threats of HCV infection in Pakistan.
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