Evidence map›Paper›PMID 23575328›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2013

Outcomes of children treated for tuberculosis with second-line medications in Georgia, 2009-2011.

M Gegia, H E Jenkins, I Kalandadze, J Furin

Abstract read
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Time to treatment for rifampicin-resistant tuberculosis: systematic review and meta-analysis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017
    Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Pediatric Multidrug-resistant Tuberculosis in Kyiv City, Ukraine.Journal of epidemiology and global health · 2019
    Article
  8. Review
  9. Global Burden of Childhood Tuberculosis.Pneumonia (Nathan Qld.) · 2016
    Article
  10. Review
  11. Epidemiology of drug-resistant tuberculosis among children and adolescents in South Africa, 2005-2010.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2015
    Article
  12. Article
  13. Article
  14. Tuberculosis in children.Mediterranean journal of hematology and infectious diseases · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

M GegiaUnited States Agency for International Development Georgia TB Prevention Project, Tbilisi, Georgia.
H E Jenkins
I Kalandadze
J Furin

Funding

Understanding and controlling antibiotic resistanceU54GM088558 · NIGMS · HARVARD SCHOOL OF PUBLIC HEALTH · PI LIPSITCH, MARC · 2009 to 2018
$26.4M
Emory-Georgia TB Research Training ProgramD43TW007124 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Nestani Tukvadze · 2004 to 2026
$4.6M
FIC NIH HHS D43 TW007124FIC NIH HHS D43TW007124NIGMS NIH HHS U54 GM088558NIGMS NIH HHS U54GM088558
6 · The paper itself

Abstract

backgroundDrug-resistant tuberculosis (DR-TB) is a major public threat in countries of the former Soviet Union, including Georgia. There are few studies of pediatric DR-TB cases, especially at a national level.

objectiveTo report the characteristics and treatment outcomes of pediatric multidrug-resistant TB (MDR-TB) cases in Georgia.

methodsWe extracted data on all pediatric (age <16 years) MDR-TB cases notified in Georgia from 2009 to 2011. We assessed the baseline and treatment characteristics and treatment outcomes of this cohort.

resultsBetween 2009 and 2011, there were 45 notified pediatric DR-TB cases in Georgia. Just over half had previously received anti-tuberculosis treatment and the median age was 7.7 years. Time from diagnosis to treatment was short (median 16 days), and the median length of treatment was 20.2 months. Of those not still on treatment, 77.1% (95%CI 61.0-87.9) had a successful outcome.

conclusionsOne of the first reports of pediatric DR-TB treatment outcomes at a national level, this study demonstrates that successful outcomes can be achieved.

Indexed as

Drug Resistance, Multiple, BacterialAdolescentAge FactorsAntitubercular AgentsChildChild, PreschoolFemaleGeorgia (Republic)HumansInfantMaleMicrobial Sensitivity TestsMycobacterium tuberculosisPredictive Value of TestsRetrospective StudiesTime FactorsAntitubercular Agents

Identifiers

PMID23575328
PMCPMC3734931

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.