ArticleChemistry Central journal2013
Influence of emulsifiers on the characteristics of polyurethane structures used as drug carrier.
Article in Chemistry Central journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Development and Preliminary Characterization of Polyester-Urethane Microparticles Used in Curcumin Drug Delivery System for Oropharyngeal Cancer.Medicina (Kaunas, Lithuania) · 2022Article
- Pleiotropic Effects of Eugenol: The Good, the Bad, and the Unknown.Oxidative medicine and cellular longevity · 2021Review
- Design and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of Acyclovir.Nanomaterials (Basel, Switzerland) · 2020Article
- An Insight into the Structural Diversity and Clinical Applicability of Polyurethanes in Biomedicine.Polymers · 2020Review
- SiOMolecules (Basel, Switzerland) · 2020Article
- Synthesis and preliminary characterization of polyurethane nanoparticles with ginger extract as a possible cardiovascular protector.International journal of nanomedicine · 2019Article
- Synthesis and characterization of a polyurethane carrier used for a prolonged transmembrane transfer of a chili pepper extract.International journal of nanomedicine · 2018Article
- A Study on the Behavior of a Polyurethane Drug Carrier in Various pH Media.Journal of medicine and lifeArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmulsifiers have a significant role in the emulsion polymerization by reducing the interfacial tension thus increasing the stability of colloidal dispersions of polymer nanostructures. This study evaluates the impact of four emulsifiers on the characteristics of polyurethane hollow structures used as drug delivery system.
resultsPolyurethane (PU) structures with high stability and sizes ranging from nano- to micro-scale were obtained by interfacial polyaddition combined with spontaneous emulsification. The pH of PU aqueous solutions (0.1% w/w) was slightly acidic, which is acceptable for products intended to be used on human skin. Agglomerated structures with irregular shapes were observed by scanning electron microscopy. The synthesized structures have melting points between 245-265°C and reveal promising results in different evaluations (TEWL, mexametry) on murine skin.
conclusionsIn this study hollow PU structures of reduced noxiousness were synthesized, their size and stability being influenced by emulsifiers. Such structures could be used in the pharmaceutical field as future drug delivery systems.
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