ArticleRadiation oncology (London, England)2013
Continuous controversy about radiation oncologists' choice of treatment regimens for bone metastases: should we blame doctors, cancer-related features, or design of previous clinical studies?
Article in Radiation oncology (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- What did COVID-19 pandemics teach us about single-fraction radiotherapy for painful bone metastases-State of the art or undertreatment?Cancer medicine · 2023Trial
- Travel distance and potential disparities in palliative radiotherapy access for cancer patients in Victoria, Australia.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Article
- Stereotactic radiotherapy for patients with bone metastases: a selected group with low rate of radiation treatment during the last month of life?Radiation oncology (London, England) · 2024Article
- Spinal Metastases of the Vertebrae: Three Main Categories of Pain.Life (Basel, Switzerland) · 2024Review
- Early death after palliative radiation treatment: 30-, 35- and 40-day mortality data and statistically robust predictors.Radiation oncology (London, England) · 2023Article
- Shortened Palliative Radiotherapy Results in a Lower Rate of Treatment During the Last Month of Life.Cureus · 2022Article
- Independent External Validation of a Score Predicting Survival After Radiotherapy for Bone Metastases and Expansion to Patients Treated With Single Fraction Radiotherapy.Journal of clinical medicine research · 2020Article
- Bone Pain in Cancer Patients: Mechanisms and Current Treatment.International journal of molecular sciences · 2019Review
- Article
- Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases.Cancers · 2018Review
- Patient-reported symptoms and performance status before palliative radiotherapy in geriatric cancer patients (octogenarians).Technical innovations & patient support in radiation oncology · 2017Article
- [Comparison of different fraction doses in single dose irradiation of painful bone metastases].Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2015Article
- International patterns of practice in radiotherapy for bone metastases: A review of the literature.Journal of bone oncology · 2014Review
- [Comparison of different fractionations in the re irradiation of painful bone metastases].Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Article
- Time evaluation of image-guided radiotherapy in patients with spinal bone metastases. A single-center study.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Article
- Palliative Radiotherapy During the Last Month of Life: Have COVID-19 Recommendations Led to Reduced Utilization?In vivo (Athens, Greece)Article
- Management of Patients With Metastatic Renal Cell Cancer and Bone Metastases.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies from Italy, Japan and Norway have confirmed previous reports, which found that a large variety of palliative radiotherapy regimens are used for painful bone metastases. Routine use of single fraction treatment might or might not be the preferred institutional approach. It is not entirely clear why inter-physician and inter-institution differences continue to persist despite numerous randomized trials, meta-analyses and guidelines, which recommend against more costly and inconvenient multi-fraction regimens delivering total doses of 30 Gy or more in a large number of clinical scenarios. In the present mini-review we discuss the questions of whether doctors are ignoring evidence-based medicine or whether we need additional studies targeting specifically those patient populations where recent surveys identified inconsistent treatment recommendations, e.g. because of challenging disease extent. We identify open questions and provide research suggestions, which might contribute to making radiation oncology practitioners more confident in selecting the right treatment for the right patient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.