ArticleBMC neurology2013
LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis.
Article in BMC neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- Genetic and Epigenetic Regulation inInternational journal of molecular sciences · 2023Article
- Association betweenInternational journal of molecular sciences · 2022Article
- Endothelial nitric oxide synthase (NOS3) rs2070744 polymorphism and risk for multiple sclerosis.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Multiple Sclerosis.Scientific reports · 2016Article
- NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis.BMC neurology · 2014Article
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Authors and funding
17 authors at 7 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSome recent experimental data suggest a possible role of LINGO-1 in the pathogenesis of multiple sclerosis (MS). In an attempt to identify genetic biomarkers related to MS susceptibility, we genotyped two common SNPs in the LINGO1 gene which have been associated to other neurological conditions, in patients with MS and in healthy subjects. These SNPs are linked to several SNPs within the LINGO1 gene, especially in individuals of Oriental or Caucasian descent.
methodsWe analyzed the allelic and genotype frequency of two LINGO1 variants (rs9652490 and rs11856808) in 293 patients with MS and 318 healthy controls, using KASPar assays.
resultsLINGO1 rs9652490 and rs11856808 allelic and genotype frequencies did not differ significantly between MS patients and controls. The minor allele frequencies for rs9652490 were 0.171 (95% CI = 0.140-0.201) and 0.167 (95% CI = 0.138-0.196 for cases and controls respectively (p = 0.853). For rs11856808 the minor allele frequencies were 0.317 (95% CI = 0.280-0.355) and 0.310 (95% CI = 0.274-0.346) for cases and controls, respectively (p = 0.773). Allele and genotype frequencies were unrelated with the age of onset of MS, gender, and clinical course of MS. In addition, haplotype analyses did not reveal any putative risk related to haplotypes.
conclusionsThese results suggest that LINGO1 rs9652490 and rs11856808 polymorphisms are not related with risk for MS. This study adds to other published evidence indicating that, to date, the LINGO1 SNPs studied here could be useful risk biomarkers of developing essential tremor, but not other movement disorders.
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