ReviewHuman pathology2013
Tissue-based identification of stem cells and epithelial-to-mesenchymal transition in breast cancer.
Review in Human pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Associations of circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with the expression of stem cell markers in benign breast tissue.Breast cancer research : BCR · 2025Article
- Cancer stem cell specificity as new targets in breast tumor treatment.Oncology research · 2025Review
- Associations of mammographic breast density with breast stem cell marker-defined breast cancer subtypes.Cancer causes & control : CCC · 2019Article
- A reproducible scaffold-free 3D organoid model to study neoplastic progression in breast cancer.Journal of cell communication and signaling · 2019Article
- Limited utility of tissue micro-arrays in detecting intra-tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer.Journal of translational medicine · 2018Article
- Collective invasion in ductal and lobular breast cancer associates with distant metastasis.Clinical & experimental metastasis · 2017Article
- Tissue-based associations of mammographic breast density with breast stem cell markers.Breast cancer research : BCR · 2017Article
- MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas.Oncogene · 2017Article
- Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model.European journal of nutrition · 2017Article
- CXCR4-SDF-1 interaction potentially mediates trafficking of circulating tumor cells in primary breast cancer.BMC cancer · 2016Article
- Periostin Facilitates the Epithelial-Mesenchymal Transition of Endometrial Epithelial Cells through ILK-Akt Signaling Pathway.BioMed research international · 2016Article
- Relationship between circulating tumor cells and epithelial to mesenchymal transition in early breast cancer.BMC cancer · 2015Article
- The role of adipose-derived stem cells in breast cancer progression and metastasis.Stem cells international · 2015Review
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Pathologists have recognized breast cancer heterogeneity for decades, but its causes were unknown. In recent years, basic science and translational studies have demonstrated that cancer stem cells contribute to the heterogeneous histologic and functional characteristics of breast cancer. Even more recently, the ability of breast epithelial cells to undergo an epithelial-to-mesenchymal transition has been linked to the acquisition of stem cells properties and enhanced tumor invasion, metastasis, and resistance to available treatments. The stem cells and cells undergoing epithelial-to-mesenchymal transition are attractive targets for therapy and breast cancer prevention. Despite current challenges, their identification in breast tissue samples would enable pathologists to discover and validate prognostic and predictive markers as well as identify markers of increased risk for breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.