ArticleBMC veterinary research2013
The ESR1 gene is associated with risk for canine mammary tumours.
Article in BMC veterinary research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Gene Expression of Hormone Receptors and Growth Factors in Intact and Neutralized Female Dogs, Both Healthy and with Cutaneous Mast Cell Tumors.Animals : an open access journal from MDPI · 2026Article
- Is PTEN rs397510595 an Unexpected Guardian in Canine Mammary Neoplasia?International journal of molecular sciences · 2025Article
- English Cocker Spaniels under primary veterinary care in the UK: disorder predispositions and protections.Canine medicine and genetics · 2024Article
- Epigenetics in Canine Mammary Tumors: Upregulation of miR-18a and miR-18b Oncogenes Is Associated with DecreasedAnimals : an open access journal from MDPI · 2023Article
- Canine as a Comparative and Translational Model for Human Mammary Tumor.Journal of breast cancer · 2023Review
- Somatic Mutation ofCancers · 2019Article
- Estrogen receptors genotypes and canine mammary neoplasia.BMC veterinary research · 2019Article
- Canine mammary tumor risk is associated with polymorphisms in RAD51 and STK11 genes.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2018Article
- A monograph proposing the use of canine mammary tumours as a model for the study of hereditary breast cancer susceptibility genes in humans.Veterinary medicine and science · 2017Review
- Genome-Wide Analysis Identifies Germ-Line Risk Factors Associated with Canine Mammary Tumours.PLoS genetics · 2016Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe limited within-breed genetic heterogeneity and an enrichment of disease-predisposing alleles have made the dog a very suitable model for the identification of genes associated with risk for specific diseases. Canine mammary cancer is an example of such a disease. However, the underlying inherited risk factors for canine mammary tumours (CMTs) are still largely unknown. In this study, 52 single nucleotide polymorphisms (SNPs) in ten human cancer-associated genes were genotyped in two different datasets in order to identify genes/alleles associated with the development of CMTs. The first dataset consisted of English Springer Spaniel (ESS) CMT cases and controls. ESS is a dog breed known to be at increased risk of developing CMTs. In the second dataset, dogs from breeds known to have a high frequency of CMTs were compared to dogs from breeds with a lower occurrence of these tumours.
resultsWe found significant associations to CMT for SNPs and haplotypes in the estrogen receptor 1 (ESR1) gene in the ESS material (best PBonf = 0.021). A large number of SNPs, among them several SNPs in ESR1, showed significantly different allele frequencies between the high and low risk breed groups (best PBonf = 8.8E-32, best PBPerm = 0.076).
conclusionsThe identification of CMT-associated SNPs in ESR1 in two independent datasets suggests that this gene might be involved in CMT development. These findings also support that CMT may serve as a good model for human breast cancer research.
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