ArticleCNS neuroscience & therapeutics2013
Impact of obesity in children with narcolepsy.
Article in CNS neuroscience & therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 83 citations in OpenAlex.
- Effect of sodium oxybate on body mass index in pediatric patients with narcolepsy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Trial
- Estimating the prevalence and clinical causality of obstructive sleep apnea in paediatric narcolepsy patients.Sleep & breathing = Schlaf & Atmung · 2024Article
- Recommended protocols for the Multiple Sleep Latency Test and Maintenance of Wakefulness Test in children: guidance from the American Academy of Sleep Medicine.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- The Changed Nocturnal Sleep Structure and Higher Anxiety, Depression, and Fatigue in Patients with Narcolepsy Type 1.Nature and science of sleep · 2024Article
- Possible Implications of Obesity-Primed Microglia that Could Contribute to Stroke-Associated Damage.Cellular and molecular neurobiology · 2023Review
- Differential characteristics of repeated polysomnography and multiple sleep latency test parameters in narcolepsy type 1 and type 2 patients: a longitudinal retrospective study.Sleep & breathing = Schlaf & Atmung · 2022Article
- Pediatric Narcolepsy-A Practical Review.Children (Basel, Switzerland) · 2022Review
- Characterization of rapid weight gain phenotype in children with narcolepsy.CNS neuroscience & therapeutics · 2022Article
- Disrupted nighttime sleep and sleep instability in narcolepsy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Review
- Narcolepsy type 1 features across the life span: age impact on clinical and polysomnographic phenotype.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Gut Microbiota in Patients with Type 1 Narcolepsy.Nature and science of sleep · 2021Article
- Recognizing the Symptom Spectrum of Narcolepsy to Improve Timely Diagnosis: A Narrative Review.Nature and science of sleep · 2021Review
- Gut microbiota composition is associated with narcolepsy type 1.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Narcolepsy with cataplexy: Does age at diagnosis change the clinical picture?CNS neuroscience & therapeutics · 2020Article
- Role of Brown Adipose Tissue in Adiposity Associated With Narcolepsy Type 1.Frontiers in endocrinology · 2020Review
- Impaired histaminergic neurotransmission in children with narcolepsy type 1.CNS neuroscience & therapeutics · 2019Article
- Unexpected Fat Distribution in Adolescents With Narcolepsy.Frontiers in endocrinology · 2018Article
- Physical Activity and Sleep/Wake Behavior, Anthropometric, and Metabolic Profile in Pediatric Narcolepsy Type 1.Frontiers in neurology · 2018Article
- A Longitudinal Follow-Up Study on Multiple Sleep Latency Test and Body Mass Index of Patients With Narcolepsy Type 1 in Korea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017Article
- The Medical and Economic Burden of Narcolepsy: Implications for Managed Care.American health & drug benefits · 2017Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate the impact of obesity on clinical and sleep characteristics in a population of narcoleptic children.
methodsData from the children diagnosed with idiopathic narcolepsy in the National Reference Centers for Narcolepsy were collected between 2008 and 2011. Clinical and electrophysiological characteristics were compared between obese (body mass index [BMI] greater than P97) and nonobese children.
resultsThe 117 children (65 boys, 59 de novo patients) had a mean age of 11.6 ± 3.1 years on diagnosis. Cataplexy was present in 81%, DQB1*0602 in 91%. Mean BMI was 23.2 ± 5.2 kg/m(2) and BMI z-score was 2.9 ± 2.6. Obesity was found in 60% with a similar prevalence in treated versus de novo patients and in patients with and without cataplexy. Sleepiness and cataplexy started earlier in obese children. Obese narcoleptic children had lower sleep efficiency, higher apnea hypopnea index and respiratory arousals index (RAI) than nonobese children. BMI z-score was positively correlated with RAI. Obese children were more tired and missed more often school than nonobese children.
conclusionObesity affects more than 50% of narcoleptic children, mostly younger at disease onset, and has a deleterious impact on sleep quality as well as on school attendance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.