ArticleCerebral cortex (New York, N.Y. : 1991)2014
Altered migratory behavior of interneurons in a model of cortical dysplasia: the influence of elevated GABAA activity.
Article in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Development of multisensory processing in ferret parietal cortex.The European journal of neuroscience · 2023Article
- Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.Frontiers in neurology · 2023Article
- The Ferret as a Model System for Neocortex Development and Evolution.Frontiers in cell and developmental biology · 2021Review
- Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2.Experimental neurobiology · 2020Article
- Article
- The Role of Redox Dysregulation in the Effects of Prenatal Stress on Embryonic Interneuron Migration.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Moving into shape: cell migration during the development and histogenesis of the cerebellum.Histochemistry and cell biology · 2018Review
- Neuronal Migration Dynamics in the Developing Ferret Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Fine-tuning of neurogenesis is essential for the evolutionary expansion of the cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Mapping arealisation of the visual cortex of non-primate species: lessons for development and evolution.Frontiers in neural circuits · 2014Review
- Targeted disruption of layer 4 during development increases GABAA receptor neurotransmission in the neocortex.Journal of neurophysiology · 2014Article
- A Career in Inquiry.The American journal of occupational therapy : official publication of the American Occupational Therapy AssociationArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Appropriate function of the neocortex depends on timely generation and migration of cells produced in the germinal zones of the neocortex and ganglionic eminence (GE). Failure to accurately complete migration results in cortical dysplasia, a developmental syndrome implicated in many neurologic disorders. We developed a model of cortical dysplasia in ferrets involving administration of methylaxozymethanol acetate (MAM), an antimitotic, to pregnant ferrets on gestational day 33, leading to dramatic reduction of layer 4 in the neocortex. Here, using time-lapse video imaging, we investigate dynamic behavior of migrating cells arising from the GE and cortical ventricular zone (CVZ) in ferrets and the role of GABAA activity. Treatment with MAM significantly reduced migration speed and the relative proportion of cells arising from the GE demonstrating exploratory behavior. To a lesser extent, the behavior of cells leaving the CVZ was affected. Pharmacologic inhibition of GABAA receptors (GABAAR) improved the speed of migration and exploratory ability of migrating MAM-treated cells arising from the GE. Additionally, the expression of α2 and α3 subunits of GABAAR and the potassium chloride co-transporter (KCC2) increased in the neocortex of MAM-treated animals. After MAM treatment, increases in endogenous KCC2 and GABAAR combine to alter the dynamic properties and exploratory behavior of migrating interneurons in ferrets. We show a direct correlation between increased GABAA and KCC2 expression with impaired migration and ability to explore the environment.
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