ArticleACS chemical neuroscience2013
Continuous online microdialysis using microfluidic sensors: dynamic neurometabolic changes during spreading depolarization.
Article in ACS chemical neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 73 citations in OpenAlex.
- Noninvasive measurement of glucose and lactate in thermoregulatory sweat in neonates and adults.Science advances · 2026Article
- 4D-Printed Redox-Responsive Needle-Flow Reactors Enabling Online Quantitative Profiling of Living Rat Brain Extracellular Lactate and Glucose.Analytical chemistry · 2025Article
- The Neurochemical Signature of Cardiac Arrest: A Multianalyte Online Microdialysis Study.ACS chemical neuroscience · 2025Article
- Microcontact printing of choline oxidase using a polycation-functionalized zwitterionic polymer as enzyme immobilization matrix.The Analyst · 2023Article
- Computational Modeling as a Tool to Drive the Development of a Novel, Chemical Device for Monitoring the Injured Brain and Body.ACS chemical neuroscience · 2023Article
- Fluidic enabled bioelectronic implants: opportunities and challenges.Journal of materials chemistry. B · 2022Review
- Fiber-based lactate recordings with fluorescence resonance energy transfer sensors by applying an magnetic resonance-informed correction of hemodynamic artifacts.Neurophotonics · 2022Article
- Monitoring Neurochemistry in Traumatic Brain Injury Patients Using Microdialysis Integrated with Biosensors: A Review.Metabolites · 2022Review
- Cortical Spreading Depolarizations in Aneurysmal Subarachnoid Hemorrhage: An Overview of Current Knowledge and Future Perspectives.Advances and technical standards in neurosurgery · 2022Review
- Fiber-Based Electrochemical Biosensors for Monitoring pH and Transient Neurometabolic Lactate.Analytical chemistry · 2021Article
- Flavin Adenine Dinucleotide Fluorescence as an Early Marker of Mitochondrial Impairment During Brain Hypoxia.International journal of molecular sciences · 2020Article
- Article
- Dexamethasone-Enhanced Microdialysis and Penetration Injury.Frontiers in bioengineering and biotechnology · 2020Review
- Portable Microfluidic Biosensing System for Real-Time Analysis of Microdialysate in Transplant Kidneys.Analytical chemistry · 2019Article
- Extended (10-Day) Real-Time Monitoring by Dexamethasone-Enhanced Microdialysis in the Injured Rat Cortex.ACS chemical neuroscience · 2019Article
- Clinical translation of microfluidic sensor devices: focus on calibration and analytical robustness.Lab on a chip · 2019Article
- Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor.Nature communications · 2019Article
- 3D printed microfluidic device for online detection of neurochemical changes with high temporal resolution in human brain microdialysate.Lab on a chip · 2019Article
- Drift Subtraction for Fast-Scan Cyclic Voltammetry Using Double-Waveform Partial-Least-Squares Regression.Analytical chemistry · 2019Article
- Skin microdialysis: methods, applications and future opportunities-an EAACI position paper.Clinical and translational allergy · 2019Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Microfluidic glucose biosensors and potassium ion selective electrodes were used in an in vivo study to measure the neurochemical effects of spreading depolarizations (SD), which have been shown to be detrimental to the injured human brain. A microdialysis probe implanted in the cortex of rats was connected to a microfluidic PDMS chip containing the sensors. The dialysate was also analyzed using our gold standard, rapid sampling microdialysis (rsMD). The glucose biosensor performance was validated against rsMD with excellent results. The glucose biosensors successfully monitored concentration changes, in response to SD wave induction, in the range of 10-400 μM with a second time-resolution. The data show that during a SD wave, there is a time delay of 62 ± 24.8 s (n = 4) between the onset of the increase in potassium and the decrease in glucose. This delay can be for the first time demonstrated, thanks to the high-temporal resolution of the microfluidic sensors sampling from a single tissue site (the microdialysis probe), and it indicates that the decrease in glucose is due to the high demand of energy required for repolarization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.