ReviewTissue engineering. Part B, Reviews2013
Monitoring cartilage tissue engineering using magnetic resonance spectroscopy, imaging, and elastography.
Review in Tissue engineering. Part B, Reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- NMR Relaxometry Across Time: From Early Insights to Emerging Directions.Magnetic resonance in chemistry : MRC · 2025Article
- Quantitative MRI methods for the assessment of structure, composition, and function of musculoskeletal tissues in basic research and preclinical applications.Magma (New York, N.Y.) · 2024Review
- Within or Without You? A Perspective Comparing In Situ and Ex Situ Tissue Engineering Strategies for Articular Cartilage Repair.Advanced healthcare materials · 2022Article
- Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin forFrontiers in bioengineering and biotechnology · 2022Article
- Emerging role of integrated PET-MRI in osteoarthritis.Skeletal radiology · 2021Review
- Medical imaging of tissue engineering and regenerative medicine constructs.Biomaterials science · 2021Review
- NMR techniques in studying water in biotechnological systems.Biophysical reviews · 2020Review
- New generation of bioreactors that advance extracellular matrix modelling and tissue engineering.Biotechnology letters · 2019Review
- Biopolymeric In Situ Hydrogels for Tissue Engineering and Bioimaging Applications.Tissue engineering and regenerative medicine · 2018Review
- Imaging Biomaterial-Tissue Interactions.Trends in biotechnology · 2018Review
- Non-invasive monitoring ofTheranostics · 2018Article
- Near-Infrared Spectroscopy Predicts Compositional and Mechanical Properties of Hyaluronic Acid-Based Engineered Cartilage Constructs.Tissue engineering. Part A · 2018Article
- Temporal development of near-native functional properties and correlations with qMRI in self-assembling fibrocartilage treated with exogenous lysyl oxidase homolog 2.Acta biomaterialia · 2017Article
- Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties.The Analyst · 2017Article
- Diamagnetic chemical exchange saturation transfer (diaCEST) affords magnetic resonance imaging of extracellular matrix hydrogel implantation in a rat model of stroke.Biomaterials · 2017Article
- Nondestructive Techniques to Evaluate the Characteristics and Development of Engineered Cartilage.Annals of biomedical engineering · 2016Review
- Biological and MRI characterization of biomimetic ECM scaffolds for cartilage tissue regeneration.Biomaterials · 2015Article
- Imaging strategies for tissue engineering applications.Tissue engineering. Part B, Reviews · 2015Review
- Biomechanics and mechanobiology in functional tissue engineering.Journal of biomechanics · 2014Review
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A key technical challenge in cartilage tissue engineering is the development of a noninvasive method for monitoring the composition, structure, and function of the tissue at different growth stages. Due to its noninvasive, three-dimensional imaging capabilities and the breadth of available contrast mechanisms, magnetic resonance imaging (MRI) techniques can be expected to play a leading role in assessing engineered cartilage. In this review, we describe the new MR-based tools (spectroscopy, imaging, and elastography) that can provide quantitative biomarkers for cartilage tissue development both in vitro and in vivo. Magnetic resonance spectroscopy can identify the changing molecular structure and alternations in the conformation of major macromolecules (collagen and proteoglycans) using parameters such as chemical shift, relaxation rates, and magnetic spin couplings. MRI provides high-resolution images whose contrast reflects developing tissue microstructure and porosity through changes in local relaxation times and the apparent diffusion coefficient. Magnetic resonance elastography uses low-frequency mechanical vibrations in conjunction with MRI to measure soft tissue mechanical properties (shear modulus and viscosity). When combined, these three techniques provide a noninvasive, multiscale window for characterizing cartilage tissue growth at all stages of tissue development, from the initial cell seeding of scaffolds to the development of the extracellular matrix during construct incubation, and finally, to the postimplantation assessment of tissue integration in animals and patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.