Evidence map›Paper›PMID 23574467›Full record

ReviewPeriodontology 20002013

Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts.

P Mark Bartold, Thomas E Van Dyke

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Periodontology 2000, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 231 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
231citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03225950 completednot on this mapstarted 2017, after this paper: background citation

Interaction Between Immune Cells and Bacteria Associated With Periodontitis

TypeobservationalSponsorUniversity of CopenhagenRan2017 to 2020Enrolled90ConditionsPeriodontal Diseases, Periodontitis, Aggressive Periodontitis, Immunologic DiseaseArmsIn vitro stimulation of blood with periodontitis-associated- and control bacteria, Anti-CCP- and anti-P.g.-antibodies titers, Analysis of selected single nucleotide polymorphisms (SNPs), periodontitis-associated bacteria presence
NCT07634341 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Clinical and Radiographic Evaluation of Doxycycline and Atorvastatin Loaded Chitosan Nanoparticles as an Adjunctive to Scaling and Root Planning in the Management of Chronic Periodontitis: A Randomized Controlled Clinical Trial.

TypeinterventionalSponsorFayoum UniversityRan2026 to 2027Enrolled80ConditionsChronic PeriodontitisArmsDoxycycline and Atorvastatin loaded Chitosan nanoparticles local drug
3 · Its place in the literature

Who cites it

231 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Periodontal Cell Therapy: A Systematic Review and Meta-analysis.Advances in experimental medicine and biology · 2022
    Pooled it
  9. The Relationship between Vitamin C and Periodontal Diseases: A Systematic Review.International journal of environmental research and public health · 2019
    Pooled it
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171 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

P Mark Bartold
Thomas E Van Dyke

Funding

Specialized Center for Oral Inflammation and ResolutionP50DE016191 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2004 to 2010
$13.6M
Neutrophils and Periodontitis in DiabetesR01DE015566 · NIDCR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI VAN DYKE, THOMAS ELLIOTT · 2005 to 2014
$4.2M
Novel Mechanisms in Resolution to Harness Inflammation for ReconstructionR01DE019938 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI IRIMIA, DANIEL, SERHAN, CHARLES NICHOLAS · 2009 to 2012
$2.7M
NIDCR NIH HHS DE15566NIDCR NIH HHS DE16191NIDCR NIH HHS DE19938NIDCR NIH HHS P50 DE016191NIDCR NIH HHS R01 DE015566NIDCR NIH HHS R01 DE019938
6 · The paper itself

Abstract

New concepts evolve when existing ones fail to address known factors adequately or are invalidated by new evidence. For decades periodontitis has been considered to be caused by specific bacteria or groups of bacteria and, accordingly, treatment protocols have largely been based on anti-infective therapies. However, close inspection of current data leads one to question whether these bacteria are the cause or the result of periodontitis. Good evidence is emerging to suggest that it is indeed the host response to oral bacteria that leads to the tissue changes noted in gingivitis. These changes lead to an altered subgingival environment that favors the emergence of 'periodontal pathogens' and the subsequent development of periodontitis if the genetic and external environmental conditions are favorable for disease development. Thus, it seems that it is indeed the initial early host-inflammatory and immune responses occurring during the development of gingivitis, and not specific bacteria or their so-called virulence factors, which determine whether periodontitis develops and progresses. In this review we consider these concepts and their potential to change the way in which we view and manage the inflammatory periodontal diseases.

Indexed as

Bacterial Physiological PhenomenaDisease ProgressionDisease SusceptibilityGingivitisHomeostasisHost-Pathogen InteractionsHumansInflammation MediatorsPeriodontitisInflammation Mediators

Identifiers

PMID23574467
PMCPMC3692012

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.