ArticleJournal of the American Chemical Society2013
Precision templating with DNA of a virus-like particle with peptide nanostructures.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 95 citations in OpenAlex.
- Nontoxic mRNA vehicles based on electrically neutral self-assembling peptides.Nature communications · 2026Article
- Central position of histidine in the sequence of designed alternating polarity peptides enhances pH-responsive assembly with DNA.BMC biotechnology · 2025Article
- Therapeutic Supramolecular Polymers: Designs and Applications.Progress in polymer science · 2024Article
- Impact of Peptide Sequences on Their Structure and Function: Mimicking of Virus-Like Nanoparticles for Nucleic Acid Delivery.Chembiochem : a European journal of chemical biology · 2023Article
- Application of Peptides in Construction of Nonviral Vectors for Gene Delivery.Nanomaterials (Basel, Switzerland) · 2022Review
- Nanoscale Structures and Materials from the Self-assembly of Polypeptides and DNA.Current topics in medicinal chemistry · 2022Review
- Supramolecular Architectures of Nucleic Acid/Peptide Hybrids.International journal of molecular sciences · 2020Review
- Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization.Pharmaceutics · 2020Review
- Structural Polymorphism of Single pDNA Condensates Elicited by Cationic Block Polyelectrolytes.Polymers · 2020Review
- From Interaction to Function in DNA-Templated Supramolecular Self-Assemblies.ChemistryOpen · 2020Review
- Synthetic Approaches for Nucleic Acid Delivery: Choosing the Right Carriers.Life (Basel, Switzerland) · 2019Review
- Supramolecular Assemblies of Peptides or Nucleopeptides for Gene Delivery.Theranostics · 2019Review
- Cell-Penetrating Peptides: Design Strategies beyond Primary Structure and Amphipathicity.Molecules (Basel, Switzerland) · 2017Review
- Programmable Assembly of Peptide Amphiphile via Noncovalent-to-Covalent Bond Conversion.Journal of the American Chemical Society · 2017Article
- Engineering responsive supramolecular biomaterials: Toward smart therapeutics.Bioengineering & translational medicine · 2016Review
- Supramolecular biomaterials.Nature materials · 2016Review
- Design and self-assembly of simple coat proteins for artificial viruses.Nature nanotechnology · 2014Article
- Learning from nature - novel synthetic biology approaches for biomaterial design.Acta biomaterialia · 2014Review
- Self-assembly of biomolecular soft matter.Faraday discussions · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We report here the preparation of filamentous virus-like particles by the encapsulation of a linear or circular double-stranded DNA template with preassembled mushroom-shaped nanostructures having a positively charged domain. These nanostructures mimic the capsid proteins of natural filamentous viruses and are formed by self-assembly of coiled-coil peptides conjugated at opposite termini with cationic segments and poly(ethylene glycol) (PEG) chains. We found that a high molecular weight of PEG segments was critical for the formation of monodisperse and uniformly shaped filamentous complexes. It is proposed that electrostatic attachment of the nanostructures with sufficiently long PEG segments generates steric forces that increase the rigidity of the neutralized DNA template. This stiffening counterbalances the natural tendency of the DNA template to condense into toroids or buckle multiple times. The control achieved over both shape and dimensions of the particles offers a strategy to create one-dimensional supramolecular nanostructures of defined length containing nucleic acids.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.