ArticleClinical and experimental immunology2013
Specific antibody deficiency in children with recurrent respiratory infections: a controlled study with follow-up.
Article in Clinical and experimental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 citations in OpenAlex.
- Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for treatment of upper respiratory tract infections in children: a pilot study on short-term efficacy.Italian journal of pediatrics · 2020Trial
- Value of allohaemagglutinins in the diagnosis of a polysaccharide antibody deficiency.Clinical and experimental immunology · 2015Trial
- Children with recurrent infections: perspective of immunoglobulin G subclasses deficiency and impaired specific antibody responses.Clinical and experimental immunology · 2025Review
- Monogenic Inborn Errors of Immunity with impaired IgG response to polysaccharide antigens but normal IgG levels and normal IgG response to protein antigens.Frontiers in pediatrics · 2024Review
- COVID-19 Co-Infection May Promote Development of Sinusitis Complication in Children.Children (Basel, Switzerland) · 2022Article
- Update on Infections in Primary Antibody Deficiencies.Frontiers in immunology · 2021Review
- Article
- Respiratory Symptoms in Post-infancy Children. A Dutch Pediatric Cohort Study.Frontiers in pediatrics · 2020Article
- Fifth Percentile Cutoff Values for Antipneumococcal Polysaccharide and Anti-Frontiers in immunology · 2017Article
- Specific Antibody Deficiency: Controversies in Diagnosis and Management.Frontiers in immunology · 2017Review
- The Challenge of Immunoglobulin-G Subclass Deficiency and Specific Polysaccharide Antibody Deficiency--a Dutch Pediatric Cohort Study.Journal of clinical immunology · 2016Article
- Pediatric recurrent respiratory tract infections: when and how to explore the immune system? (About 53 cases).The Pan African medical journal · 2016Article
- Cartilage-hair hypoplasia: follow-up of immunodeficiency in two patients.Journal of clinical immunology · 2014Article
- An update on the use of immunoglobulin for the treatment of immunodeficiency disorders.Immunotherapy · 2014Review
- Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe.Frontiers in immunology · 2014Review
- Association of recurrent upper respiratory tract infections with low production of oxygen intermediates in children.Jornal de pediatriaArticle
- Pidotimod in the treatment of pediatric recurrent respiratory tract infection.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Specific antibody deficiency (SAD) to unconjugated pneumococcal vaccine (PPV) is an established primary B cell immunodeficiency. The occurrence and natural history of SAD in children is unclear. We conducted an observational study to identify SAD in children with recurrent respiratory infections. Ninety-nine children, mean age 5·9 (range 2-16) years, with recurrent or severe infections were vaccinated with PPV; serum antibody concentrations for serotypes 4, 6B, 9V, 14, 18C, 19F and 23F were measured before and 2 weeks after vaccination with enzyme immunoassay. The retrospective control group consisted of 89 healthy children matched for age and gender. No children had received previous conjugated pneumococcal vaccine (PCV) or PPV. The structured history of infectious diseases of all participants was collected. Ten of 91 (11%) children (eight excluded due to immunoglobulin G subclass deficiency) with recurrent respiratory infections had SAD. In the control group, three children (3%) responded inadequately to PPV (P = 0·05). Most children with SAD also had many other minor immune defects. After 0·5-5 years (medium 3·8), eight children with SAD were revaccinated with PPV; five responded adequately and three inadequately. Two SAD children were revaccinated with PCV, one developed an adequate and one an inadequate response. Two children with SAD received treatment with intravenous immunoglobulin; the remaining eight children recovered without replacement therapy during the follow-up. SAD is common in young children with recurrent respiratory infections, but it is often transient and resolves itself within a few years without specific treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.