ArticleInternational journal of hypertension2013
Immunohistochemical Localization of AT1a, AT1b, and AT2 Angiotensin II Receptor Subtypes in the Rat Adrenal, Pituitary, and Brain with a Perspective Commentary.
Article in International journal of hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Brain sodium sensing for regulation of thirst, salt appetite, and blood pressure.Physiological reports · 2024Review
- A kidney-brain neural circuit drives progressive kidney damage and heart failure.Signal transduction and targeted therapy · 2023Article
- The Angiotensin ATPharmacological reviews · 2022Review
- Central regulation of body fluid homeostasis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2022Review
- Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review.International journal of molecular sciences · 2021Review
- Angiotensin receptors and neuropathic pain.Pain reports · 2021Review
- Recent Advances in the Endogenous Brain Renin-Angiotensin System and Drugs Acting on It.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2021Review
- Moderate Physical Exercise Activates ATRFrontiers in physiology · 2021Article
- Obesity: sex and sympathetics.Biology of sex differences · 2020Review
- Severe food restriction activates the central renin angiotensin system.Physiological reports · 2020Article
- Telmisartan, an Antagonist of Angiotensin II Receptors, Accentuates Voltage-Gated NaFrontiers in neuroscience · 2020Article
- The promise of zebrafish as a model of metabolic syndrome.Experimental animals · 2019Review
- ATAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Article
- Effect of Chronic Intermittent Hypoxia on Angiotensin II Receptors in the Central Nervous System.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2018Article
- Targeting Renin-Angiotensin System Against Alzheimer's Disease.Frontiers in pharmacology · 2018Review
- Angiotensin II AT2 Receptors Contribute to Regulate the Sympathoadrenal and Hormonal Reaction to Stress Stimuli.Cellular and molecular neurobiology · 2018Review
- Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ.Nature neuroscience · 2017Article
- New Insights in the Functional Zonation of the Canine Adrenal Cortex.Journal of veterinary internal medicine · 2016Article
- Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system.Brain structure & function · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiotensin II increases blood pressure and stimulates thirst and sodium appetite in the brain. It also stimulates secretion of aldosterone from the adrenal zona glomerulosa and epinephrine from the adrenal medulla. The rat has 3 subtypes of angiotensin II receptors: AT1a, AT1b, and AT2. mRNAs for all three subtypes occur in the adrenal and brain. To immunohistochemically differentiate these receptor subtypes, rabbits were immunized with C-terminal fragments of these subtypes to generate receptor subtype-specific antibodies. Immunofluorescence revealed AT1a and AT2 receptors in adrenal zona glomerulosa and medulla. AT1b immunofluorescence was present in the zona glomerulosa, but not the medulla. Ultrastructural immunogold labeling for the AT1a receptor in glomerulosa and medullary cells localized it to plasma membrane, endocytic vesicles, multivesicular bodies, and the nucleus. AT1b and AT2, but not AT1a, immunofluorescence was observed in the anterior pituitary. Stellate cells were AT1b positive while ovoid cells were AT2 positive. In the brain, neurons were AT1a, AT1b, and AT2 positive, but glia was only AT1b positive. Highest levels of AT1a, AT1b, and AT2 receptor immunofluorescence were in the subfornical organ, median eminence, area postrema, paraventricular nucleus, and solitary tract nucleus. These studies complement those employing different techniques to characterize Ang II receptors.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.