ArticleAmerican journal of translational research2013
Cytokine dysregulation associated with malarial anemia in Plasmodium yoelii infected mice.
Article in American journal of translational research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Immune Modulation by Plasmodium yoelii: Insights From Lethal and Non-Lethal Strains.Parasite immunology · 2026Review
- Targeting anemia-induced CD71Infection and immunity · 2025Article
- Pharmacologic Inhibition of Erythrocyte Ferroportin Expression ExacerbatesMicroorganisms · 2025Article
- Antimalarial Efficacy of Ethanol Extract of Bridelia micrantha Stem Bark against Plasmodium berghei-Infected Mice.Journal of parasitology research · 2024Article
- Immunomodulatory effects of testosterone and letrozole duringFrontiers in cellular and infection microbiology · 2023Article
- Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya.Tropical medicine and health · 2022Article
- Macrophage migration inhibitory factor contributes to immunopathogenesis duringFrontiers in cellular and infection microbiology · 2022Article
- The Potential Role ofJournal of tropical medicine · 2021Article
- Contributions of IFN-γ and granulysin to the clearance of Plasmodium yoelii blood stage.PLoS pathogens · 2020Article
- Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum.BMC medical genetics · 2019Article
- ELF4 facilitates innate host defenses againstThe Journal of biological chemistry · 2019Article
- Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans.TheScientificWorldJournal · 2019Article
- Inducible Costimulator Expressing T Cells Promote Parasitic Growth During Blood StageFrontiers in immunology · 2018Article
- Host immune response is severely compromised during lethal Plasmodium vinckei infection.Parasitology research · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The mechanisms of malaria anemia remain incompletely understood although much effort has been put on studies in both human and murine systems. Hematopoiesis is regulated by the proliferation, differentiation and maturation of erythropoietic progenitor cells into erythrocytes and is tightly controlled by a complex communication network of cytokines as signal mediators. The present study used the murine P. yoelii 17XNL malaria model to investigate the profile of cytokines and leukocytes throughout the entire infection. Moreover, malaria induced anemia was studied in comparison with anemia induced by hemorrhage and hemolysis. During the P. yoelii infection, the levels of erythropoietic-related cytokines, such as G-CSF, GMCSF, IL-7, and IL-17, were pronouncedly reduced, while those of regulatory cytokines, such as IL-10 and TNF-α, were constantly increased. This cytokine profile corresponded well with the cellular composition during the infection, such as drastically decreased levels of CD4(+) and CD8(+) T cells. The cytokine profile during malarial anemia showed the same characteristics as anemia induced by hemorrhage or hemolysis. This study demonstrates that a markedly dysregulated cytokine network occurred in this murine malaria model, which may open a new window of insight into the mechanisms of malaria related anemia.
Indexed as
Identifiers
23573367PMC3612518W1724850287What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.