ArticleAmerican journal of translational research2013
Prefrontal lactate predicts exercise-induced cognitive dysfunction in Gulf War Illness.
Article in American journal of translational research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Exercise does not cause post-exertional malaise in Veterans with Gulf War Illness: A randomized, controlled, dose-response, crossover study.Brain, behavior, and immunity · 2024Trial
- Exercise - induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects.Scientific reports · 2017Trial
- Exercise-induced changes in gene expression do not mediate post exertional malaise in Gulf War illness.Brain, behavior, & immunity - health · 2023Article
- Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans.Psychopharmacology · 2023Review
- The Department of Veterans Affairs Gulf War Veterans' Illnesses Biorepository: Supporting Research on Gulf War Veterans' Illnesses.Brain sciences · 2021Article
- Gulf War veterans exhibit broadband sleep EEG power reductions in regions overlying the frontal lobe.Life sciences · 2021Article
- Predicting post-exertional malaise in Gulf War Illness based on acute exercise responses.Life sciences · 2021Article
- Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies.Pharmacology & therapeutics · 2021Review
- Vagus Nerve Stimulation Ameliorates Cognitive Impairment and Increased Hippocampal Astrocytes in a Mouse Model of Gulf War Illness.Neuroscience insights · 2021Article
- An analysis of 2-day cardiopulmonary exercise testing to assess unexplained fatigue.Physiological reports · 2020Article
- Transcranial Photobiomodulation to Improve Cognition in Gulf War Illness.Frontiers in neurology · 2020Article
- Leveraging Prior Knowledge to Recover Characteristic Immune Regulatory Motifs in Gulf War Illness.Frontiers in physiology · 2020Article
- Veterans with Gulf War Illness exhibit distinct respiratory patterns during maximal cardiopulmonary exercise.PloS one · 2019Article
- Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model.Frontiers in immunology · 2018Review
- Subcortical brain atrophy in Gulf War Illness.Experimental brain research · 2017Article
- A Neuroimmune Model of Gulf War Illness.Journal of environment and health sciences · 2017Article
- Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness.Frontiers in molecular neuroscience · 2017Article
- Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment.Cortex; a journal devoted to the study of the nervous system and behavior · 2016Review
- Characterizing "fibrofog": Subjective appraisal, objective performance, and task-related brain activity during a working memory task.NeuroImage. Clinical · 2016Article
- Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness.Journal of neurochemistry · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
background25% to 30% of Veterans deployed to the 1990 to 1991 Persian Gulf War exhibit an idiopathic syndrome of chronic fatigue, exertional exhaustion, pain, hyperalgesia, cognitive and affective dysfunction known as Gulf War Illness (GWI).
methodsGulf War veterans (n=15) and sedentary veteran and civilian controls (n=11) completed a 2-back working memory test in an fMRI before and after two bicycle exercise stress test. We performed single voxel (1)H MRS to evaluate brain metabolic differences in the left anterior cingulate cortex and the changes associated with exercise.
resultsEight GWI subjects increased their 2-back scores after exercise (labelled increasers) and seven GWI subjects decreased their 2-back scores after exercise (labelled decreasers). These phenotypic responses were absent for controls. Decreasers had significantly elevated prefrontal lactate levels compared to Increasers prior to completion of the exercise stress tests. Evaluation of prefrontal lactate levels prior to exercise demonstrated predictability (ROC analysis) of the two diametrically opposed subgroups.
conclusionPrefrontal lactate levels may be a potential biomarker for exercise-induced subgroups in GWI. The alterations in brain energetics may be in part responsible for a subgroup of GWI and underlie some of the symptoms present in the patient population.
Indexed as
Identifiers
23573365PMC3612516W1489787184What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.