Evidence map›Paper›PMID 23573330›Full record

ArticleInternational journal of clinical and experimental pathology2013

Cytokeratin positivity in anaplastic large cell lymphoma: a potential diagnostic pitfall in misdiagnosis of metastatic carcinoma.

Qingfu Zhang, Jian Ming, Siyang Zhang, Bo Li, Xue Han, Xueshan Qiu

Open access · greenAbstract readCase Reports
In one paragraph

Article in International journal of clinical and experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qingfu ZhangDepartment of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, PR China.
Jian Ming
Siyang Zhang
Bo Li
Xue Han
Xueshan Qiu
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytokeratin (pan) and epithelial membrane antigen (EMA) were considered as commonly useful epithelial markers to distinguish cancer from lymphoma, but the expression of cytokeratin (pan) and EMA had also been seen in some lymphomas. Here, we presented an unusual case of anaplastic large cell lymphoma (ALCL) absence of some lymphoid markers (Including CD3, CD20, Pax-5, CD45Ro) and positive for cytokeratin (pan) and EMA, which was misdiagnosed as metastatic carcinoma. Our case suggested that the epithelial markers (including cytokeratin and EMA) show an overlap with that of ALCL, which represented a diagnostic pitfall for confusing ALCL with metastatic carcinoma.

Indexed as

Diagnostic ErrorsAdultBiomarkers, TumorBiopsyHumansIntracellular Signaling Peptides and ProteinsKeratinsKi-1 AntigenLymphatic MetastasisLymph NodesLymphoma, Large-Cell, AnaplasticMaleMucin-1Nuclear ProteinsProteinsBiomarkers, TumorIntracellular Signaling Peptides and ProteinsKeratinsKi-1 AntigenMucin-1Nuclear ProteinsProteinsWDR48 protein, humanAnaplastic large cell lymphomaanaplastic lymphoma kinaseimmunohistochemistry

Identifiers

PMID23573330
PMCPMC3606873
OpenAlexW32294896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.