ArticlePloS one2013
Regulatory patterns of a large family of defensin-like genes expressed in nodules of Medicago truncatula.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Widely conserved AHL transcription factors are essential for NCR gene expression and nodule development in Medicago.Nature plants · 2023Article
- Plant circadian clock control of Medicago truncatula nodulation via regulation of nodule cysteine-rich peptides.Journal of experimental botany · 2022Article
- A variable gene family encoding nodule-specific cysteine-rich peptides in pea (Frontiers in plant science · 2022Article
- Legume Plant Peptides as Sources of Novel Antimicrobial Molecules Against Human Pathogens.Frontiers in molecular biosciences · 2022Article
- Genome-wide analysis of autophagy-related genes in Medicago truncatula highlights their roles in seed development and response to drought stress.Scientific reports · 2021Article
- How Rhizobia Adapt to the Nodule Environment.Journal of bacteriology · 2021Article
- Possible role of small secreted peptides (SSPs) in immune signaling in bryophytes.Plant molecular biology · 2021Article
- Secretory Peptides as Bullets: Effector Peptides from Pathogens against Antimicrobial Peptides from Soybean.International journal of molecular sciences · 2020Review
- Symbiotic Outcome Modified by the Diversification from 7 to over 700 Nodule-Specific Cysteine-Rich Peptides.Genes · 2020Review
- Gene Expression in Nitrogen-Fixing Symbiotic Nodule Cells inThe Plant cell · 2020Review
- Antimicrobial Activities of Cysteine-rich Peptides Specific to Bacteriocytes of the Pea Aphid Acyrthosiphon pisum.Microbes and environments · 2019Article
- Article
- Nitrate application or P deficiency induce a decline in Medicago truncatula NScientific reports · 2017Article
- A proteomic atlas of the legume Medicago truncatula and its nitrogen-fixing endosymbiont Sinorhizobium meliloti.Nature biotechnology · 2016Article
- Genome-Wide Identification and Expression Analysis of the 14-3-3 Family Genes in Medicago truncatula.Frontiers in plant science · 2016Article
- Loss of the nodule-specific cysteine rich peptide, NCR169, abolishes symbiotic nitrogen fixation in the Medicago truncatula dnf7 mutant.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- An antimicrobial peptide essential for bacterial survival in the nitrogen-fixing symbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Rapid turnover of antimicrobial-type cysteine-rich protein genes in closely related Oryza genomes.Molecular genetics and genomics : MGG · 2015Article
- Genome-wide identification and expression analysis of auxin response factor gene family in Medicago truncatula.Frontiers in plant science · 2015Article
- Extreme specificity of NCR gene expression in Medicago truncatula.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Root nodules are the symbiotic organ of legumes that house nitrogen-fixing bacteria. Many genes are specifically induced in nodules during the interactions between the host plant and symbiotic rhizobia. Information regarding the regulation of expression for most of these genes is lacking. One of the largest gene families expressed in the nodules of the model legume Medicago truncatula is the nodule cysteine-rich (NCR) group of defensin-like (DEFL) genes. We used a custom Affymetrix microarray to catalog the expression changes of 566 NCRs at different stages of nodule development. Additionally, bacterial mutants were used to understand the importance of the rhizobial partners in induction of NCRs. Expression of early NCRs was detected during the initial infection of rhizobia in nodules and expression continued as nodules became mature. Late NCRs were induced concomitantly with bacteroid development in the nodules. The induction of early and late NCRs was correlated with the number and morphology of rhizobia in the nodule. Conserved 41 to 50 bp motifs identified in the upstream 1,000 bp promoter regions of NCRs were required for promoter activity. These cis-element motifs were found to be unique to the NCR family among all annotated genes in the M. truncatula genome, although they contain sub-regions with clear similarity to known regulatory motifs involved in nodule-specific expression and temporal gene regulation.
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