ArticlePloS one2013
Identification of genetic variation on the horse y chromosome and the tracing of male founder lineages in modern breeds.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 79 citations in OpenAlex.
- Integrative Advances in Equine Genomics From Reference Assemblies to Evolutionary History and Key Traits.Evolutionary applications · 2026Review
- High-quality, haplotype-resolved reference genomes of the Dutch warmblood horse and Friesian horse using trio binning.BMC genomics · 2025Article
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- A Genetic Make Up of Italian Lipizzan Horse Through Uniparental Markers to Preserve Historical Pedigrees.Biology · 2024Article
- The global spread of Oriental Horses in the past 1,500 years through the lens of the Y chromosome.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Biomolecular evidence reveals mares and long-distance imported horses sacrificed by the last pagans in temperate Europe.Science advances · 2024Article
- Mitochondrial DNA sequencing of Kehilan and Hamdani horses from Saudi Arabia.Saudi journal of biological sciences · 2023Article
- Article
- Characteristic of Przewalski horses population from Askania-Nova reserve based on genetic markers.Molecular biology reports · 2023Article
- Exploring the Italian equine gene poolFrontiers in genetics · 2023Article
- Unlocking Horse Y Chromosome Diversity.Genes · 2022Review
- Development and validation of a horse reference panel for genotype imputation.Genetics, selection, evolution : GSE · 2022Article
- Y-Chromosomal Insights into Breeding History and Sire Line Genealogies of Arabian Horses.Genes · 2022Article
- Mitochondrial DNA analysis of ancient sheep from Kazakhstan: evidence for early sheep introduction.Heliyon · 2021Article
- Current genetic conservation of Chinese indigenous horses revealed with Y-chromosomal and mitochondrial DNA polymorphisms.G3 (Bethesda, Md.) · 2021Article
- Genetic characterization of Kushum horses in Kazakhstan based on haplotypes of mtDNA and Y chromosome, and genes associated with important traits of the horses.Journal of equine science · 2020Article
- Genetic Diversity and Population Structure of Polish Konik Horse Based on Individuals from All the Male Founder Lines and Microsatellite Markers.Animals : an open access journal from MDPI · 2020Article
- A Genetic Window on Sardinian Native Horse Breeds through Uniparental Molecular Systems.Animals : an open access journal from MDPI · 2020Article
- Genome Diversity and the Origin of the Arabian Horse.Scientific reports · 2020Article
- Ancient Patrilineal Lines and Relatively High ECAY Diversity Preserved in Indigenous Horses Revealed With Novel Y-Chromosome Markers.Frontiers in genetics · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The paternally inherited Y chromosome displays the population genetic history of males. While modern domestic horses (Equus caballus) exhibit abundant diversity within maternally inherited mitochondrial DNA, no significant Y-chromosomal sequence diversity has been detected. We used high throughput sequencing technology to identify the first polymorphic Y-chromosomal markers useful for tracing paternal lines. The nucleotide variability of the modern horse Y chromosome is extremely low, resulting in six haplotypes (HT), all clearly distinct from the Przewalski horse (E. przewalskii). The most widespread HT1 is ancestral and the other five haplotypes apparently arose on the background of HT1 by mutation or gene conversion after domestication. Two haplotypes (HT2 and HT3) are widely distributed at high frequencies among modern European horse breeds. Using pedigree information, we trace the distribution of Y-haplotype diversity to particular founders. The mutation leading to HT3 occurred in the germline of the famous English Thoroughbred stallion "Eclipse" or his son or grandson and its prevalence demonstrates the influence of this popular paternal line on modern sport horse breeds. The pervasive introgression of Thoroughbred stallions during the last 200 years to refine autochthonous breeds has strongly affected the distribution of Y-chromosomal variation in modern horse breeds and has led to the replacement of autochthonous Y chromosomes. Only a few northern European breeds bear unique variants at high frequencies or fixed within but not shared among breeds. Our Y-chromosomal data complement the well established mtDNA lineages and document the male side of the genetic history of modern horse breeds and breeding practices.
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