ArticleEvidence-based complementary and alternative medicine : eCAM2013
Zhen gan xi feng decoction, a traditional chinese herbal formula, for the treatment of essential hypertension: a systematic review of randomized controlled trials.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-analysis of the effectiveness of traditional Chinese herbal formula Zhen Wu Decoction for the treatment of hypertension.BMJ open · 2015Pooled it
- The effect of Chinese herbal medicine Jian Ling Decoction for the treatment of essential hypertension: a systematic review.BMJ open · 2015Pooled it
- Pooled it
- Observational
- Quanduzhong capsules for the treatment of grade 1 hypertension patients with low-to-moderate risk: A multicenter, randomized, double-blind, placebo-controlled clinical trial.Frontiers in pharmacology · 2022Article
- Influence of Dietary Components and Traditional Chinese Medicine on Hypertension: A Potential Role for Gut Microbiota.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Traditional Chinese Medicine for Essential Hypertension: A Clinical Evidence Map.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Therapeutic Efficacy and Safety of Traditional Chinese Medicine Classic Herbal FormulaFrontiers in pharmacology · 2018Article
- Puerarin and betahistine treatment of vertebrobasilar ischemia vertigo: A meta-analysis of randomized controlled trials.Experimental and therapeutic medicine · 2016Article
- Traditional chinese medicine syndromes for essential hypertension: a literature analysis of 13,272 patients.Evidence-based complementary and alternative medicine : eCAM · 2014Review
- Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern science.Hypertension research : official journal of the Japanese Society of Hypertension · 2013Review
- Trends in the treatment of hypertension from the perspective of traditional chinese medicine.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Chinese herbal medicine qi ju di huang wan for the treatment of essential hypertension: a systematic review of randomized controlled trials.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Evidence-based chinese medicine for hypertension.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Chinese herbal medicine for the treatment of obesity-related hypertension.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Tianma gouteng yin as adjunctive treatment for essential hypertension: a systematic review of randomized controlled trials.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Chinese herbal medicine for the treatment of prehypertension.Evidence-based complementary and alternative medicine : eCAM · 2013Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives. To assess the clinical effectiveness and adverse effects of Zhen Gan Xi Feng Decoction (ZGXFD) for essential hypertension (EH). Methods. Five major electronic databases were searched up to August 2012 to retrieve any potential randomized controlled trials designed to evaluate the clinical effectiveness of ZGXFD for EH reported in any language, with main outcome measure as blood pressure (BP). Results. Six randomized trials were included. Methodological quality of the trials was evaluated as generally low. Four trials compared prescriptions based on ZGXFD with antihypertensive drugs. Meta-analysis showed that ZGXFD was more effective in BP control and TCM syndrome and symptom differentiation (TCM-SSD) scores than antihypertensive drugs. Two trials compared the combination of modified ZGXFD plus antihypertensive drugs with antihypertensive drugs. Meta-analysis showed that there is significant beneficial effect on TCM-SSD scores. However, no significant effect on BP was found. The safety of ZGXFD is still uncertain. Conclusions. ZGXFD appears to be effective in improving blood pressure and hypertension-related symptoms for EH. However, the evidence remains weak due to poor methodological quality of the included studies. More rigorous trials are warranted to support their clinical use.
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Registered trials
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