ArticleAdvances in bioinformatics2013
Gene regulation, modulation, and their applications in gene expression data analysis.
Article in Advances in bioinformatics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Advancing translational exposomics: bridging genome, exposome and personalized medicine.Human genomics · 2025Review
- MICFuzzy: A maximal information content based fuzzy approach for reconstructing genetic networks.PloS one · 2023Article
- Brain Cancer Prediction Based on Novel Interpretable Ensemble Gene Selection Algorithm and Classifier.Diagnostics (Basel, Switzerland) · 2021Article
- Fuzzy methods for the detection of copy number variations in comparative genomic hybridization arrays.Saudi journal of biological sciences · 2020Article
- Identification and characterization of methylation-mediated transcriptional dysregulation dictate methylation roles in preeclampsia.Human genomics · 2020Article
- Identification of long non‑coding RNA‑mediated transcriptional dysregulation triplets reveals global patterns and prognostic biomarkers for ER+/PR+, HER2‑ and triple negative breast cancer.International journal of molecular medicine · 2019Article
- JAMI: fast computation of conditional mutual information for ceRNA network analysis.Bioinformatics (Oxford, England) · 2018Article
- Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer.BMC genomics · 2017Article
- Identification and characterization of lncRNA mediated transcriptional dysregulation dictates lncRNA roles in glioblastoma.Oncotarget · 2016Article
- Differential network analysis reveals the genome-wide landscape of estrogen receptor modulation in hormonal cancers.Scientific reports · 2016Article
- Classification of Microarray Data Using Kernel Fuzzy Inference System.International scholarly research notices · 2014Article
- Bifidobacterium bifidum PRL2010 modulates the host innate immune response.Applied and environmental microbiology · 2014Article
- Emerging roles of competing endogenous RNAs in cancer: insights from the regulation of PTEN.Molecular and cellular biology · 2013Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Common microarray and next-generation sequencing data analysis concentrate on tumor subtype classification, marker detection, and transcriptional regulation discovery during biological processes by exploring the correlated gene expression patterns and their shared functions. Genetic regulatory network (GRN) based approaches have been employed in many large studies in order to scrutinize for dysregulation and potential treatment controls. In addition to gene regulation and network construction, the concept of the network modulator that has significant systemic impact has been proposed, and detection algorithms have been developed in past years. Here we provide a unified mathematic description of these methods, followed with a brief survey of these modulator identification algorithms. As an early attempt to extend the concept to new RNA regulation mechanism, competitive endogenous RNA (ceRNA), into a modulator framework, we provide two applications to illustrate the network construction, modulation effect, and the preliminary finding from these networks. Those methods we surveyed and developed are used to dissect the regulated network under different modulators. Not limit to these, the concept of "modulation" can adapt to various biological mechanisms to discover the novel gene regulation mechanisms.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.