ArticleProceedings of the National Academy of Sciences of the United States of America2013
Circuit-level input integration in bacterial gene regulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Mixed positive and negative feedback loops drive diverse single-cell gene expression dynamics.Nature communications · 2026Article
- Maximization of information transmission influences selection of native phosphorelay architectures.PeerJ · 2021Article
- Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.Cell systems · 2018Article
- Molecular Time Sharing through Dynamic Pulsing in Single Cells.Cell systems · 2018Article
- Impact of Zygosity on Bimodal Phenotype Distributions.Biophysical journal · 2017Article
- Mechanosensing of shear byProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Noise Expands the Response Range of the Bacillus subtilis Competence Circuit.PLoS computational biology · 2016Article
- Fitness Trade-Offs in Competence Differentiation of Bacillus subtilis.Frontiers in microbiology · 2016Article
- Secreting and sensing the same molecule allows cells to achieve versatile social behaviors.Science (New York, N.Y.) · 2014Article
- Noise in biology.Reports on progress in physics. Physical Society (Great Britain) · 2014Review
- Evidence for phenotypic bistability resulting from transcriptional interference of bvgAS in Bordetella bronchiseptica.Molecular microbiology · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Gene regulatory circuits can receive multiple simultaneous inputs, which can enter the system through different locations. It is thus necessary to establish how these genetic circuits integrate multiple inputs as a function of their relative entry points. Here, we use the dynamic circuit regulating competence for DNA uptake in Bacillus subtilis as a model system to investigate this issue. Specifically, we map the response of single cells in vivo to a combination of (i) a chemical signal controlling the constitutive expression of key competence genes, and (ii) a genetic perturbation in the form of copy number variation of one of these genes, which mimics the level of stress signals sensed by the bacteria. Quantitative time-lapse fluorescence microscopy shows that a variety of dynamical behaviors can be reached by the combination of the two inputs. Additionally, the integration depends strongly on the relative locations where the two perturbations enter the circuit. Specifically, when the two inputs act upon different circuit elements, their integration generates novel dynamical behavior, whereas inputs affecting the same element do not. An in silico bidimensional bifurcation analysis of a mathematical model of the circuit offers good quantitative agreement with the experimental observations, and sheds light on the dynamical mechanisms leading to the different integrated responses exhibited by the gene regulatory circuit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.