ArticleThe Journal of biological chemistry2013
Putrescine importer PlaP contributes to swarming motility and urothelial cell invasion in Proteus mirabilis.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- PstSCAB and SapBCDF are putrescine exporters inMicrobiology spectrum · 2026Article
- Article
- Salmonella Typhimurium exploits host polyamines for assembly of the type 3 secretion machinery.PLoS biology · 2024Article
- Article
- Polyamine signaling communications play a key role in regulating the pathogenicity ofMicrobiology spectrum · 2023Article
- Polyamines: their significance for maintaining health and contributing to diseases.Cell communication and signaling : CCS · 2023Review
- Cultured Bacteria Provide Insight into the Functional Potential of the Coral-Associated Microbiome.mSystems · 2022Article
- Polyamine and Ethanolamine Metabolism in Bacteria as an Important Component of Nitrogen Assimilation for Survival and Pathogenicity.Medical sciences (Basel, Switzerland) · 2022Review
- Dickeya Manipulates Multiple Quorum Sensing Systems to Control Virulence and Collective Behaviors.Frontiers in plant science · 2022Review
- The expansive effects of polyamines on the metabolism and virulence of Streptococcus pneumoniae.Pneumonia (Nathan Qld.) · 2021Review
- Putrescine Is an Intraspecies and Interkingdom Cell-Cell Communication Signal Modulating the Virulence ofFrontiers in microbiology · 2019Article
- Pathogenesis ofEcoSal Plus · 2018Review
- Article
- A Novel Putrescine Exporter SapBCDF of Escherichia coli.The Journal of biological chemistry · 2016Article
- Invasion of Host Cells and Tissues by Uropathogenic Bacteria.Microbiology spectrum · 2016Review
- Proteus mirabilis and Urinary Tract Infections.Microbiology spectrum · 2015Review
- Effects of norspermidine and spermidine on biofilm formation by potentially pathogenic Escherichia coli and Salmonella enterica wild-type strains.Applied and environmental microbiology · 2015Article
- Arginine promotes Proteus mirabilis motility and fitness by contributing to conservation of the proton gradient and proton motive force.MicrobiologyOpen · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Previously, we reported that the speA gene, encoding arginine decarboxylase, is required for swarming in the urinary tract pathogen Proteus mirabilis. In addition, this previous study suggested that putrescine may act as a cell-to-cell signaling molecule (Sturgill, G., and Rather, P. N. (2004) Mol. Microbiol. 51, 437-446). In this new study, PlaP, a putative putrescine importer, was characterized in P. mirabilis. In a wild-type background, a plaP null mutation resulted in a modest swarming defect and slightly decreased levels of intracellular putrescine. In a P. mirabilis speA mutant with greatly reduced levels of intracellular putrescine, plaP was required for the putrescine-dependent rescue of swarming motility. When a speA/plaP double mutant was grown in the presence of extracellular putrescine, the intracellular levels of putrescine were greatly reduced compared with the speA mutant alone, indicating that PlaP functioned as the primary putrescine importer. In urothelial cell invasion assays, a speA mutant exhibited a 50% reduction in invasion when compared with wild type, and this defect could be restored by putrescine in a PlaP-dependent manner. The putrescine analog Triamide-44 partially inhibited the uptake of putrescine by PlaP and decreased both putrescine stimulated swarming and urothelial cell invasion in a speA mutant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.