ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2013
Are we ready for an outpatient parenteral antimicrobial therapy bundle? A critical appraisal of the evidence.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Quality Indicators for Appropriate Outpatient Parenteral Antimicrobial Therapy in Adults: A Systematic Review and RAND-modified Delphi Procedure.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Pooled it
- Quality indicators assessing antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure.The Journal of antimicrobial chemotherapy · 2018Pooled it
- Outpatient Parenteral Antimicrobial Therapy Practice Variability Across Veterans Affairs Hospitals.JAMA network open · 2026Article
- Outpatient Parenteral Antimicrobial Therapy in a Tertiary Hospital in France: A Description of Service Models and Costs.Antibiotics (Basel, Switzerland) · 2025Article
- Outpatient parenteral antimicrobial therapy (OPAT) across the world: a comparative analysis-what lessons can we learn?JAC-antimicrobial resistance · 2024Review
- Creation and Validation of an Automated Registry for Outpatient Parenteral Antibiotics.Open forum infectious diseases · 2024Article
- Stability Study of Fosfomycin in Elastomeric Pumps at 4 °C and 34 °C: Technical Bases for a Continuous Infusion Use for Outpatient Parenteral Antibiotic Therapy.Pharmaceutics · 2023Article
- Clinical Efficacy and Safety of Vancomycin Continuous Infusion in Patients Treated at Home in an Outpatient Parenteral Antimicrobial Therapy Program.Antibiotics (Basel, Switzerland) · 2022Article
- Stability of Antimicrobials in Elastomeric Pumps: A Systematic Review.Antibiotics (Basel, Switzerland) · 2021Review
- Evaluating the safety and effectiveness of a nurse-led outpatient virtual IV vancomycin monitoring clinic: a retrospective cohort study.JAC-antimicrobial resistance · 2021Article
- Paediatric Outpatient Parenteral Antimicrobial Therapy (OPAT): An e-survey of the experiences of parents and clinicians.PloS one · 2021Article
- Perspectives of Patients on Outpatient Parenteral Antimicrobial Therapy: Experiences and Adherence.Open forum infectious diseases · 2020Article
- Comparisons of 30-Day Admission and 30-Day Total Healthcare Costs Between Patients Who Were Treated With Oritavancin or Vancomycin for a Skin Infection in the Outpatient Setting.Open forum infectious diseases · 2019Article
- Updated good practice recommendations for outpatient parenteral antimicrobial therapy (OPAT) in adults and children in the UK.JAC-antimicrobial resistance · 2019Review
- Outpatient parenteral antimicrobial therapy and antibiotic stewardship: opponents or teammates?Infection · 2019Review
- The impact of an infectious disease expert team on outpatient parenteral antimicrobial treatment in the Netherlands.International journal of clinical pharmacy · 2019Article
- Outpatient ertapenem therapy in an ESBL-high-prevalence area: an efficacy, safety, and cost study.Infection and drug resistance · 2019Article
- Risk factors for readmission in patients discharged with outpatient parenteral antimicrobial therapy: a retrospective cohort study.BMC pharmacology & toxicology · 2018Article
- Utilizing a Modified Care Coordination Measurement Tool to Capture Value for a Pediatric Outpatient Parenteral and Prolonged Oral Antibiotic Therapy Program.Journal of the Pediatric Infectious Diseases Society · 2018Article
- Outpatient Parenteral Antimicrobial Therapy in Pediatric Medicaid Enrollees.Journal of the Pediatric Infectious Diseases Society · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Healthcare "bundles" have been developed to help providers improve the reliability and delivery of essential healthcare processes. Bundles have been shown to be effective in reducing healthcare-associated infection rates and are increasingly used to ensure the quality of patient care. Outpatient parenteral antimicrobial therapy (OPAT) is now standard medical practice in the treatment of a wide variety of infections. We review 6 components that we believe comprise an OPAT bundle and the evidence supporting each: patient selection, infectious disease consultation, patient/caregiver education, discharge planning, outpatient monitoring/tracking, and OPAT program review. To ensure that patients are receiving optimal care, further program development and outcomes research should target these bundle components to bring the evidence base up to date with current medical practices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.