ArticlePsychopharmacology2014
Adolescence: a time of transition for the phenotype of dcc heterozygous mice.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks.Molecular psychiatry · 2025Review
- Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice.Nature communications · 2023Article
- Mesocorticolimbic Dopamine Pathways Across Adolescence: Diversity in Development.Frontiers in neural circuits · 2021Review
- Exposure to methylphenidate during peri-adolescence decouples the prefrontal cortex: a multimodal MRI study.American journal of translational research · 2021Article
- The Netrin-1/DCC Guidance Cue Pathway as a Molecular Target in Depression: Translational Evidence.Biological psychiatry · 2020Review
- Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- NF-κB-vimentin is involved in steroidogenesis stimulated by di-Toxicology research · 2018Article
- Making Dopamine Connections in Adolescence.Trends in neurosciences · 2017Review
- Dcc haploinsufficiency regulates dopamine receptor expression across postnatal lifespan.Neuroscience · 2017Article
- Resilience to amphetamine in mouse models of netrin-1 haploinsufficiency: role of mesocortical dopamine.Psychopharmacology · 2015Article
- Amphetamine in adolescence disrupts the development of medial prefrontal cortex dopamine connectivity in a DCC-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Protracted maturation of forebrain afferent connections of the ventral tegmental area in the rat.The Journal of comparative neurology · 2014Article
- Netrin-1 receptor-deficient mice show age-specific impairment in drug-induced locomotor hyperactivity but still self-administer methamphetamine.Psychopharmacology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleStark differences exist between adult (>PND 70) and juvenile (∼PND 21-34) rodents in how DCC (deleted in colorectal cancer) receptors and sensitization to amphetamine interact. In adults, repeated amphetamine upregulates DCC receptor expression selectively in the ventral tegmental area (VTA), an effect that is critical for sensitization. In contrast, amphetamine administered to juveniles downregulates VTA DCC expression. Moreover, whereas adult dcc heterozygous mice fail to sensitize when repeatedly treated with amphetamine, drug treatment during the juvenile period actually abolishes this adult "protective" phenotype.
objectivesWe set out to determine whether adolescence (PND ∼35-55) is a period during which: (1) amphetamine-induced alterations in VTA DCC expression switch from downregulation to upregulation; (2) the "protective" phenotype of adult dcc heterozygotes against sensitization becomes evident; and (3) the adult "protective" phenotype of dcc heterozygotes can still be abolished by repeated amphetamine treatment.
resultsRepeated amphetamine did not significantly alter VTA DCC expression in adolescent rodents when assessed 1 week later. Both wild-type and dcc heterozygous mice exhibited sensitization at this time. Remarkably, wild-type mice, but not dcc heterozygotes, exhibited sensitization when tested during adulthood.
conclusionsAdolescence is a time of transition for dcc heterozygotes as related to sensitization. Our results support the hypothesis that DCC may be a key factor in determining age-dependent individual differences in vulnerability to sensitization. Given that exposure to drugs of abuse during adolescence can have profound consequences for adulthood, the resilience of adult dcc heterozygous mice against adolescent exposure to amphetamine is particularly salient.
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